瘤内注射型卡铂缓释微球制备初步研究  

Primary Study on Preparation of Carboplatina-loaded PLGA Microphere for Intratumoral Injection

作　　者：邓伟[1] 卓忠雄[1] 刘容[1] 朱铭[1] 徐颖[1] 高云华[1] 

机构地区：[1]第三军医大学新桥医院超声科,400037

出　　处：《临床超声医学杂志》2003年第1期1-3,共3页Journal of Clinical Ultrasound in Medicine

摘　　要：目的　制备适宜于超声引导局部注射治疗肿瘤的载药缓释剂———卡铂 乳酸羟基乙酸共聚物微球。方法　采用W O W复乳法、恒温磁力搅拌制备卡铂 乳酸羟基乙酸共聚物缓释微球 ,并观察其物理特征和体外缓释效果。结果　制备的缓释微球粒径范围为 5～ 2 0 0 μm ,10～ 10 0 μm的微球数目为 90 .1% ,包封率为 68.3% ,载药率为15 .3% ,缓释时间持续 96h以上。结论　卡铂Objective To prepare carboplatina-loaded.PLGA microspheres for intratumoral injection guided by ultrasound.Methods Carboplatina-loaded PLGA microspheres were developed by the method of W/O/W double emulsion and magnetic stir,and their physical character and release effect were observed.Results The size of character ranged from 5 to 200 μm,AR and DL were 68.3% and 15.3% respectively.The release time lasted over than 96 h.Conclusions The carboplatina-loaded PLGA microspheres fit the intratumoral injection.

关 键 词：卡铂 控制释放 介入超声 制备 

分 类 号：R979.1[医药卫生—药品]