白术对大鼠肠道乙酰胆碱酯酶及P物质分布的影响  

The effect of Atractylodes macrocephala on the distribution of acetylcholinesterase and substance P in jejunum of rats

作　　者：朱金照[1] 冷恩仁[2] 张捷[1] 许其增[1] 

机构地区：[1]南京军区福州总医院消化内科,福建福州350025 [2]第三军医大学大坪医院消化内科,重庆400038

出　　处：《中国现代应用药学》2003年第1期14-16,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的　观察白术对大鼠空肠乙酰胆碱酯酶 (AchE)、P物质 (SP)阳性神经分布的影响。方法　 3 2只Wistar大鼠随机分成 3个不同剂量白术组及对照组 ,给大鼠灌服不同剂量白术煎液 6h后 ,采用组化法显示空肠肌间神经丛AchE阳性神经分布 ,免疫组化法观察空肠SP阳性神经分布的变化。结果　白术能明显增加空肠肌间神经丛中AchE阳性神经的含量 (P <0 .0 1)及空肠黏膜下和肌间神经丛中SP阳性神经的含量 (P <0 .0 5 )。结论　白术可通过影响空肠AchE 。OBJECTIVE To observe the effect of Atractylodes macrocephala on distributions of AchE and SP positive nerve in Jejunum of rats. METHOD 32 Wistar rats were randomly divided into different Atractylodes macrocephala group and control group. After the rats were given different dose of Atractylodes macrocephala decoction for 6 hour, distribution of AchE positive nerve in jejunal myenteric nerve plexus was showed by histochemistry; the immunohistochemistry was used to investigated the distribution of SP positive nerve in jejunum.RESULTS Distributions of AchE positive nerve in jejunal myenteric nerve plexus and SP positive nerve in jejunal myenteric nerve plexus as well as jejunal submucosa of rats increased significantly after Atractylodes macrocephala decoction was given.CONCLUSION The increased distributions of AchE and SP positive nerve in jejunum may play some role in the prokinetic effects on intestine of Atractylodes macrocephala .

关 键 词：白术 乙酰胆碱脂酶 P物质 肠道运动 药理 中药 

分 类 号：R282.710.5[医药卫生—中药学]