稀释剂对HPMC骨架片释药的影响  

The effect of diluents on the release rate of insoluble drug from HPMC hydrogel matrix

作　　者：许东航[1] 范辉[2] 叶婷[3] 梁文权[3] 

机构地区：[1]浙江大学医学院附属二院,浙江杭州310009 [2]浙江大学医学院附属邵逸夫医院,浙江杭州310016 [3]浙江大学药学院,浙江杭州310006

出　　处：《中国现代应用药学》2003年第1期30-32,共3页Chinese Journal of Modern Applied Pharmacy

基　　金：浙江省自然科学基金资助

摘　　要：目的　探讨稀释剂对难溶性药物的HPMC骨架片释药的影响。方法　以甲氧苄胺嘧啶、卡马西平、磺胺甲 口 恶 唑和茶碱四种难溶型性药物为模型药物 ,测定三种相同剂量的稀释剂 (糊精、乳糖和磷酸氢钙 )时药物的释放度。结果　甲氧苄胺嘧啶、卡马西平、磺胺甲 口恶 唑的释药速率为糊精 >乳糖 >磷酸氢钙 ;而茶碱的释药速率为糊精≈乳糖 >磷酸氢钙。OBJECTIVE The effect of different diluents on the release rate of insoluble drug from HPMC hydrogel matrix was investigated. METHOD trimethoprim?carbamazepine?sulfamethoxazole and theophylline were employed as model drugs,the rates of drugs release were determined respectively with 3 different diluents(dextrin,lactose,calcium hydrogen phosphate).RESULTS The experiments showed that the rate of drug release which influenced by diluents were dextrin>lactose>calcium hydrogen phosphate in trimethoprim, carbamazepine, sulfamethoxazole matrix tablets.The effect of dextrin on the rate of drug release influenced by lactose,but faster than that which influenced by calcium hydrogen phosphate.CONCLUSION The effect of different diluents on the release rate of insoluble drug maybe related to the machanism of drug release from HPMC hydrogel matrix.

关 键 词：难溶性药物 HPMC骨架片 稀释剂 释放度 

分 类 号：R944[医药卫生—药剂学]