ClC-3氯通道研究进展  

Progress in the study of ClC-3 chloride channel

作　　者：张海宁[1] 关永源[1] 

机构地区：[1]中山大学中山医学院药理学教研室,广州510080

出　　处：《中国药理学通报》2003年第2期125-129,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助课题 (No 39970 849);广东省自然科学基金团队项目CMB (No 0 0 730 );国家科技部攀登计划 (国科基字[1999] 0 45 )资助项目

摘　　要：容积敏感性氯通道普遍存在于哺乳动物细胞 ,对维持细胞容积平衡、调节细胞电活动等多种生理功能发挥重要作用。ClC 3作为可能编码ICl.swell的基因 ,受到广泛关注。本文就近年来对ClC 3氯通道在通道特点。Volume-sensitive chloride channels are now known to be ubiquitously present in mammalian cells. They are required for the regulation of cell volume, electrical activity and so on. ClC-3 is studied as a most likely candidate to encode a volume-sensitive chloride channels in the hands of several groups. The review is supposed to provide a broad overview of progress in the recent years, including the characterization of the channel, their presumed physiological roles, the regulation mechanism of ClC-3 chloride channel, etc.

关 键 词：研究进展 CLC-3 氯通道 组织分布 ICL SWELL 

分 类 号：Q51[生物学—生物化学]