调血脂药物与肌病、横纹肌溶解症  

Lipid-regulators and myopathy, rhabdomyolysis

作　　者：孙霞[1] 吴葆杰[1] 张岫美[1] 

机构地区：[1]山东大学医学院药理学研究所,济南250012

出　　处：《中国药理学通报》2003年第2期130-133,共4页Chinese Pharmacological Bulletin

摘　　要：有报道指出 ,调血脂药物他汀类、烟酸、贝特类等可导致严重的不良反应如肌病 ,甚至是危及病人生命的横纹肌溶解症。本文对肌病、横纹肌溶解症的发病及其与调血脂药的关系 ,调血脂药引发肌病、横纹肌溶解症的机制 ,以及主要导致肌病、横纹肌溶解症的因素 ,进行了综述讨论 ,以便加深认识 ,防止此类病症的发生 。It is reported that lipid-regulators including statins, nicotinic acid and fibrates can induce severe adverse reactions such as myopathy, even rhabdomyolysis which endangers the patient's life. The authors have discussed the relationship between lipid-regulators and myopathy, rhabdomyolysis, how those drugs cause these adverse reactions and the major factors for myopathy and rhabdomyolysis in order to deepen the knowledge, prevent the happenness of these diseases and develop the more effective and safer lipid-regulators.

关 键 词：拜斯亭 吉非贝齐 烟酸 肌病 横纹肌溶解症 

分 类 号：R685.05[医药卫生—骨科学]