淫羊藿总黄酮对大鼠实验性骨质疏松生化学指标的影响  

Influence of total flavonoids of herba epimedii on the biochemical index of osteoporosis in rats

作　　者：马慧萍[1] 贾正平[1] 白孟海[1] 葛欣[1] 何晓英[1] 陈克明[2] 

机构地区：[1]兰州军区兰州总医院药材科,兰州730050 [2]兰州军区兰州总医院骨科研究所,兰州730050

出　　处：《中国药理学通报》2003年第2期187-190,共4页Chinese Pharmacological Bulletin

基　　金：全军"十五"规划重点课题 ;No 0 1Z0 0 8

摘　　要：目的　探讨淫羊藿总黄酮防治大鼠实验性骨质疏松症过程中骨代谢生化指标的变化及其意义。方法　采用维甲酸灌胃造成大鼠实验性骨质疏松症模型 ,检测灌服高、中、低 3种剂量的淫羊藿总黄酮后大鼠血清生化指标、尿生化指标、骨矿含量及骨密度指标的变化 ,并与模型组、正常对照组和阳性对照组进行比较。结果　 3个剂量组的血清E2 、T和BGP水平均高于模型组 ,尿Ca/Cr、DPD和血清PTH水平均低于模型组 ,股骨Ca、P和骨密度与正常对照组接近 ,与模型组差异有显著性。结论　淫羊藿总黄酮对维甲酸造成的大鼠骨质疏松症有明显的防治作用 ,骨代谢生化指标变化情况与骨密度的变化相一致 。AIM To investigate the changes of biochemical index of osteoporosis in rats induced by given total flavonoids of herba epimedii (HEF) . METHODS The rat osteoporosis was induced by given retinoic acid intragastrically, the biochemical index in serum (T, E 2, ALP, PTH, BGP, Osteocalcin ) and in urine (Ca, P, DPD and Cr) were determined after the rats were given HEF by low, middle and high dosages respectively, and were compared with the model group. The normal control and the positive control. RESULTS The E 2, T and BGP level in all three dosage groups were obviously higher than that of the model group. The Ca/Cr, DPD and PTH level were obviously lower than the model group. The content of Ca and P and the bone density in femur were similar with the normal control, and there was significant difference compared with the model group. CONCLUSION HEF prevents the rats treated by retinoic acid from becoming osteoporosis. The changes of biochemical index were consistent with the variation of bone density, indicating the great significance of biochemical index in diagnosis and treatment of osteoporosis.

关 键 词：淫羊藿总黄酮 大鼠 实验性骨质疏松 生化学指标 影响 

分 类 号：R681.05[医药卫生—骨科学]