石胆草中苯乙醇苷的分离与结构鉴定  

Isolation and structural identification of phenylethanoid glycosides from Corallodiscus flabellata

作　　者：郑晓珂[1] 李军[1] 冯卫生[1] 毕跃峰[1] 冀春茹[1] 

机构地区：[1]河南中医学院,河南郑州450008

出　　处：《药学学报》2003年第2期116-119,共4页Acta Pharmaceutica Sinica

基　　金：河南省高校杰出科研人才创新工程项目( 2 0 0 3KYCX0 0 2 );河南省杰出青年科学基金资助项目 ( 0 2 12 0 0 12 0 0 )

摘　　要：目的　研究石胆草 (Corallodiscusflabellata)的化学成分。方法　利用大孔吸附树脂、SephadexLH 2 0、硅胶柱色谱进行分离纯化 ,根据化合物的理化性质和光谱数据鉴定结构。结果　分离并鉴定了 3个新的苯乙醇苷类化合物 ,经光谱鉴定化合物的结构为 :3 ,4 二羟基苯乙醇 8 O [β D 芹糖基 ( 1→ 3 ) ] β D 葡糖苷 (I) ,3 ,4 二羟基苯乙醇 8 O [4 O 咖啡酰基 β D 芹糖基 ( 1→ 3 ) β D 葡糖基 ( 1→ 6) ] β D 葡糖苷 (II) ,3 ,4 二羟基苯乙醇 8 O [β D 芹糖基 ( 1→3 ) β D 葡糖基 ( 1→ 6) ] β D 葡糖苷 (III)。 结论　I。Aim To study the chemical constituents from Corallodiscus flabellata . Methods The compounds were isolated and purified by macroporous adsorption resin, silica gel column chromatography and identified on the basis of their physiochemical and spectral data. Results Three phenylethanoid glycosides (I-III) were obtained from the n BuOH fraction of water extracts. Their structures were elucidated as 3,4 dihydroxyphenylethanol 8 O [β D apiofuranosyl (1→3)] β D glucopyranoside (I), 3,4 dihydroxyphenylethanol 8 O [4 O trans caffeoyl β D apiofuranosyl(1→3) β D glucopyranosyl (1→6)] β D glucopyranoside (II) and 3,4 dihydroxyphenylethanol 8 O [β D apiofuranosyl(1→3) β D glucopyranosyl (1→6)] β D glucopyranoside (III). Conclusion Compounds I, II and III are new compounds.

关 键 词：石胆草 苯乙醇苷 分离 结构鉴定 

分 类 号：R284.1[医药卫生—中药学]