尼龙六六盐粉尘对大鼠肺致纤维化实验研究  

Experimental Study on Pulmonary Fibrosis of Nylon-66-salt Particulate in Rat

作　　者：邓虹[1] 韩明禄[1] 白宜忠[1] 

机构地区：[1]辽宁省疾病预防控制中心,辽宁沈阳110005

出　　处：《工业卫生与职业病》2003年第1期33-35,共3页Industrial Health and Occupational Diseases

摘　　要：目的　研究尼龙六六盐粉尘对大鼠肺的致纤维化作用。方法　采用大鼠被动式粉尘吸入法染尘 ,以肺组织形态学改变为观察指标 ,并参考支气管肺泡灌洗 (BAL)的实验结果。结果　实验组大鼠肺病理切片上可见轻度的网织纤维增生和少量胶原纤维 ,石英粉尘对照组可见明显的纤维化 ,两者差异有显著性。BAL实验组的各项指标实验组均高于正常对照组 ,低于石英粉尘组。Objective To study the pulmonary fibrosis of nylon 66 salt particulate in rat.Methods Rats were exposed to nylon 66 salt particulate by passive inhalation.Pulmonary morphologic changes and broncho alveolar lavage(BAL)were observed.Results For nylon 66 salt group,slight reticular fiber proliferation and some collagen fiber were found on the pathological sections of rat lung tissue.Quartz group,however,showed significant pulmonary fibrosis.Other experimental indexes in nylon 66 salt group were higher than those in control group,but lower than in quartz group.Conclusions Nylon 66 salt particulate might lead to slight pulmonary fibrosis.

关 键 词：尼龙六六盐粉尘 纤维化 大鼠 肺 胶原纤维 网织纤维 

分 类 号：R135.2[医药卫生—劳动卫生]