Chemo-and radio-protective effects of polysaccharide of Spirulina platensis on hemopoietic system of mice and dogs  

螺旋藻多糖对小鼠和犬造血系统的化学和放射防护作用(英文)

作　　者：张洪泉[1] 林安平[1] 孙云 邓杨梅 

机构地区：[1]扬州大学医药研究所,扬州中国225001

出　　处：《Acta Pharmacologica Sinica》2001年第12期1121-1124,共4页中国药理学报（英文版）

摘　　要：AIM: To observe polysaccharide of Spirulina platensis (PSp) on the hematopoietic system of mouse and dogs which were damaged by injection of cyclophosphamide (CTX) and 60Co-γ irradiation. METHODS: CTX and 60Co-γ ray were used to induce bone marrow damage, and the experimental animals were ig with different dose of PSp in vivo, after 12-d and 21-d administration, the whole blood cells and nucleated cells in bone marrow were measured, and the DNA in bone marrow were inspected by UV-spectrophotometer. RESULTS: CTX and 60Co-γ irradiation induced hemopoietic system damage in mice and dogs, respectively. PSp 30, 60 mg/kg increased the level of the white cells in blood and nucleated cells and DNA in bone marrow in mice but had no effects on red cells and hemoglobins. PSp 12 mg/kg increased the level of red cells, white cells, and hemoglobins in blood and nucleated cells in bone marrow in dogs (P < 0.01), and the effects of PSp 60 mg/kg were better than that of berbamine hydrochloride 60 mg/ kg. CONCLUSION: PSp has chemo-protective and radio-protective capability, and may be a potential adjunct to cancer therapy.目的:研究螺旋藻多糖(PSp)对环磷酰胺和^(60)CO-γ射线所致小白鼠和犬造血系统抑制的影响。方法:腹腔注射环磷酰胺以及用^(60)CO-γ射线照射分别诱发小鼠和犬的骨髓损伤。全血细胞计数和骨髓有核细胞计数。用紫外分光光度计检测骨髓DNA的含量。结果:环磷酰胺和^(60)CO-γ射线分别造成小鼠和犬骨髓造血系统抑制性损伤。PSp 30,60mg/kg能升高小鼠全血白细胞数和骨髓有核细胞数以及DNA含量;PSp 12mg/kg能使犬骨髓有核细胞数,以及外周血红细胞、白细胞及血红蛋白水平得以回升(P<0.01),其疗效优于盐酸小壁胺。结论:PSp对造血系统有化学保护和放射保护作用。

关 键 词：Spirulina platensis POLYSACCHARIDES bone marrow gamma rays radiation-protective agents HEMOGLOBINS erythrocyte count leukocyte count 

分 类 号：R285[医药卫生—中药学]