麝香鼻康灵的主要药效学研究  

MAIN PHARMACODYNAMICS OF SHEXIANGBIKANGLING

作　　者：郭芳[1] 师晨霞[1] 孟祥琴[1] 郭鸣放[1] 刘秀书[1] 武占军[1] 宋建徽[1] 张永健[1] 王永利[1] 

机构地区：[1]河北医科大学基础医学院药理学教研室,河北石家庄050017

出　　处：《河北医科大学学报》2003年第2期94-96,共3页Journal of Hebei Medical University

摘　　要：目的探讨麝香鼻康灵的主要药效学。方法采用大鼠离体后肢血管阻力、二甲苯致小鼠耳肿胀及致敏豚鼠回肠平滑肌过敏性收缩试验。结果麝香鼻康灵 17、5 1、170mg/kg可提高大鼠离体后肢血管阻力 (P <0 .0 5和 0 .0 1) ;麝香鼻康灵 30mg/kg明显减轻二甲苯所致小鼠耳廓炎症 (P <0 .0 5 ) ;麝香鼻康灵 0 .85、2 .5 5、8.5mg/kg显著抑制致敏豚鼠回肠肌的过敏性收缩 (P <0 .0 1)。结论麝香鼻康灵具有收缩血管、抗炎和抗变态反应的作用。ObjectiveTo observe the main pharmacodyn amics of Shexiangbikangling (SXBKL).MethodsIsolated blood vessel, ear edema and Schulty Dale reaction were used.ResultsSXBKL dose dependently increased vascular resistance (P< 0.05 ,P< 0.01 ), SXBKL 30 mg/kg reduced ear edema degree (P< 0.05 ),and inhibited allergic contraction of guinea pig ileum (P< 0.01 ).ConclusionSXBKL may produce therapeutic effect on stuffy nose through vascular contraction, anti inflammation and anti allergy.

关 键 词：麝香鼻康灵 药理学 鼻堵塞 药物疗法 血管阻力 炎症 

分 类 号：R285.5[医药卫生—中药学]