α_1胸腺肽加快免疫妥协的宿主体内T细胞中介的中和抗体产生的恢复  

Thymosin α_1 accelerates restoration of T cell-mediated neutralizing antibody response in immunocompromised hosts

作　　者：张婷[1] 李善昌[2] 王淑秋[1] 

机构地区：[1]佳木斯大学基础医学院,黑龙江佳木斯154007 [2]佳木斯大学附属口腔医院,黑龙江佳木斯154002

出　　处：《黑龙江医药科学》2003年第1期6-7,共2页Heilongjiang Medicine and Pharmacy

摘　　要：α1 胸腺肽是生物反应的修饰因子 ,临床上已被应用于慢性乙肝病人的治疗。我们建立了一个新的动物模型及相应条件 ,通过测定乙肝病毒的表面抗体的生成量来估价胸腺肽活性。证明了化学合成的α1 胸腺肽恢复由 5 - Fu诱发的免疫抑制中 T细胞中介的抗体产量。发现 α1 胸腺肽在 30 ug/ kg的低剂量下显示活性。流式细胞仪分析表明 ,α1 胸腺肽在此剂量加快胸腺细胞的成熟 ,是根据 CD4 - CD8-胸腺细胞上 Hh信号的 Sm o分子的表达确定的 ,- Sm o是增生反应的潜在阴性调节者。本篇研究提供了在乙肝病毒感染中Thymosin α 1 is a biological response modifier that has been used clinically for the treatment of chronic hepatitis B viral infection.Here, we established a new animal model and the related suitable conditions to access the thymosin activity by measuring the production of neutralizing antibody against hepatitis B surface antigen (HBsAg). We proved that chemically synthesized thymosinα 1 restored the T cell-mediated antibody production following its supression in mice by 5-fluorouracil(5-Fu).and found that thymosin α 1,showed activity at a low dose of 30 ug/kg Further studies by the flowcytometric analysis showed that thymosin α 1 at this dose accelerated the replenishment and maturation of thymocytes while the expression of Smoothened (Smo) of the Hedgehog (Hh)-signaling in CD 4 -CD 8 -thymocytes, Smo being the potent negative regulator of proliferative responses, was not affected.The restoration of some of the defects in the host defense systems may facilitate elimination of infectious agents,and the present study provides a novel model to define the restoration of T cell -mediated immune responses to hepatitis B virus in vivo.

关 键 词：Α1胸腺肽 乙型肝炎病毒 乙型肝炎病毒感染 

分 类 号：R512.62[医药卫生—内科学]