烧伤患者血浆D-乳酸水平和肠道内IgA含量的变化  

Changes in plasma D-lactate and intestinal IgA levels in severe burn patients

作　　者：于勇[1] 盛志勇[1] 柴家科[1] 黎君友[1] 杨晓东[2] 袁仕安[2] 晋桦[1] 董宁[1] 孙丹[1] 

机构地区：[1]解放军第304医院全军烧伤研究所,北京100037 [2]解放军第159医院全军烧伤中心,河南驻马店460008

出　　处：《创伤外科杂志》2003年第2期122-124,共3页Journal of Traumatic Surgery

摘　　要：目的　探讨大面积烧伤患者肠道屏障损伤的规律。方法　采用分光光度法和酶联法分别测定16例大面积烧伤患者血浆D 乳酸水平和肠道内免疫球蛋白A(IgA)含量。结果　伤后血浆D 乳酸水平明显升高 ,各时相点均明显高于健康对照 ,并于伤后第 3周达到最高点 ;同期肠道内IgA含量明显减少 ,于伤后的第 2周达到最低点 ;烧伤面积 >5 0 %的患者上述指标的变化幅度大于烧伤面积 <5 0 %的患者。结论　烧伤后肠道屏障的损伤涉及机械屏障和免疫屏障等多方面 ;应采用不同的方法、从不同角度入手保护烧伤患者肠道屏障。Objective To investigate the underlying mechanism of intestinal barrier injury in severe burn patients.?Methods Plasma D lactate level and fecal IgA level of burn patients were measured with spectrophotometric assay and ELISA respectively.?Results A significant increase in plasma D lactate was observed and its level reached peak in the third week after burn. A marked decrease in intestinal IgA level was found,and it decreased to its lowest level in the second week after burn.?Conclusion The results suggested that many factors were involved in disruption of intestinal mucosal barrier function,and the decrease of IgA might play a role in it. Therefore,it seems to be important that distinct protective measures should be taken to maintain the intestinal barrier function of burn patients in various ways.

关 键 词：肠道屏障 烧伤 D-乳酸 免疫球蛋白A 

分 类 号：R644－33[医药卫生—外科学]