硝苯地平溶液的光解动力学研究  

Studies on photodecomposition kinetics of nifedipine solution

作　　者：赵卫权[1] 崔黎丽[1] 周长江[1] 林锦明[1] 詹先成[2] 

机构地区：[1]第二军医大学药学院无机化学教研室,上海200433 [2]四川大学华西药学院物理化学教研室

出　　处：《第二军医大学学报》2003年第2期210-213,共4页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金 (3 9770 882 )

摘　　要：目的 :研究硝苯地平溶液光解反应的动力学规律和影响因素 ,探讨药物光稳定性的研究方法。方法 :在日光灯、紫外灯和自然光照射下对不同浓度硝苯地平溶液进行强制降解实验。结果 :硝苯地平溶液在自然光和日光灯下的光解动力学规律基本相同 ,溶液的浓度影响药物对光的吸收 :低浓度溶液的光解为一级反应 ;高浓度时光解反应趋向于零级反应 ,光解反应速率常数与光的照度成线性关系。 结论 :硝苯地平溶液光解的速率主要决定于照射光的性质。Objective:To study the photodecomposition kinetics of nifedipine solution and the reaction mechanism, and to present the method for studying the photostability of drugs. Methods:Forced degradation testing was carried out at different concentration nifedipine solution while fluorescent lamp, ultraviolet lamp or daylight was employed. Results: The photodecomposition rate was linear with the illuminance of light. The disappearance of nifedipine solution at lower concentrations was best described by apparent first order kinetics, while at higher concentrations zero order kinetics was followed. Conclusion:The photodecomposition rate of nifedipine solution largely depends on the illuminance of light and the absorption of light by the drug.

关 键 词：硝苯地平 光解动力学 光稳定性 

分 类 号：R972[医药卫生—药品]