氨氯地平对映体的高效毛细管电泳手性拆分  

Enantiomeric Separation of Amlodipine by High Performance Capillary Electrophoresis

作　　者：姜廷福[1] 梁冰[1] 李菊白[1] 李辰[1] 欧庆瑜[1] 

机构地区：[1]中国科学院兰州化学物理研究所,兰州730000

出　　处：《分析科学学报》2003年第1期33-35,共3页Journal of Analytical Science

摘　　要：建立了氨氯地平对映体的高效毛细管电泳手性拆分方法。考察了背景电解质的 p H值和浓度、手性选择剂浓度、有机改性剂种类及浓度对分离的影响 ,对分离条件进行了优化。结果表明 :在含 3 0 mg/ m L 羟丙基 -β-CD( HP-β-CD)和 1 0 %甲醇的40 mmol/ L Tris-H3 PO4 ( p H2 .5)体系中 ,对映体达到基线分离 ,分离度 ( RS)为 3 .4。The enantiomers of amlodipine were successfully separated by high performance capillary electrophoresis using HP-β-CD as a chiral selector. Effects of the pH and concentration of buffer, concentration of HP-β-CD, and type and concentration of organic modifier on the resolution of amlodipine enantiomers were investigated. The resolution were improved greatly by the addition of 10% CH 3OH.

关 键 词：氨氯地平 对映体 毛细管电泳 手性拆分 手性分离 HP-β-CD 抗高血压药物 

分 类 号：R972[医药卫生—药品] R914.4[医药卫生—药学]