血液相容生医材料的合成研究15 苯乙烯型磺酸铵内盐单体的合成及其聚合物的抗血小板粘附性能  

Synthesis of a Styrenoid Sulfobetaine and Research on the Platelet Adhesion of Its Homopolymer

作　　者：袁江[1] 沈健[1] 林思聪[1] 

机构地区：[1]南京大学表面和界面化学工程技术研究中心,南京210093

出　　处：《应用化学》2003年第3期269-271,共3页Chinese Journal of Applied Chemistry

基　　金：973国家重点基础研究发展规划项目 (G19990 6 470 5)

摘　　要：A kind of sulfobetaine, N,N-dimethyl-N-(3- sulfopropyl )-4-ethen yl-benzenemethanaminium inner salt was synthesized from tertiary amine and propanesultone and characterized by IR a nd 1 H NMR . The blood compatibilities of the polymers were evaluate d by platelet adhesion method. No platelet adhesion in platelet rich plasma(PRP) was observed for two hours.A kind of sulfobetaine, N,N-dimethyl-N-(3- sulfopropyl )-4-ethen yl-benzenemethanaminium inner salt was synthesized from tertiary amine and propanesultone and characterized by IR a nd 1 H NMR . The blood compatibilities of the polymers were evaluate d by platelet adhesion method. No platelet adhesion in platelet rich plasma(PRP) was observed for two hours.

关 键 词：磺酸铵内盐 合成 聚合物 抗血小板粘附性能. 两性离子不凝血生物材料 医用生物材料 血液相容性 

分 类 号：R318.08[医药卫生—生物医学工程]