猴头多糖(HEPS)遗传毒性评价及抗突变实验研究  

Evaluation of genetic toxicity and antimutagenicity of HEPS

作　　者：聂继盛[1] 祝寿芬[1] 

机构地区：[1]山西医科大学卫生毒理学教研室,太原030001

出　　处：《山西医科大学学报》2003年第1期33-34,共2页Journal of Shanxi Medical University

基　　金：山西省教育厅科技开发基金资助项目 (1996)

摘　　要：目的与方法　采用经典Ames试验评价猴头多糖 (HEPS)的遗传毒性及抗突变作用。结果　HEPS 3 0mg/皿、15mg/皿、7 5mg/皿、3 75mg/皿、1 875mg/皿 5个剂量组在 +S9和 -S9时 ,均未能引起TA 98和TA 10 0两测试菌株回变菌落数增加 ,亦未观察到剂量反应关系。本次研究HEPS 2 0mg/皿、10mg/皿、5mg/皿三个剂量组都可显著抑制阳性物敌克松和叠氮钠引起的TA 10 0回变菌落数增加 (P <0 0 5 )。结论　本实验条件下HEPS致突变作用阴性 ,HEPS具有抗突变作用。Objective To research the genetic toxicityand antimutagenicity of hericium erinaceus polysaccharides(HEPS). Methods By Ames test, genetic toxicity and antimutagenicity of HEPS was evaluated. Results HEPS showed no significant increase of the revertants of TA 98 and TA 100 at doses of 30 mg/plate, 15 mg/plate, 7 5 mg/plate, 3 75 mg/plate and 1 875mg/plate, and the dose response relationship was not observed. However, the revertants of TA 100 induced by dexon and sodium azide(NaN 3)were significantly inhibited by HEPS at doses 20 mg/plate, 10 mg/plate and 5 mg/plate compared withthe positive control group. Conclusion HEPS shows no mutagenicity,suggesting it has antimutagenicity.

关 键 词：猴头多糖 遗传毒性 抗突变作用 AMES试验 

分 类 号：R961[医药卫生—药理学]