COMBINATORIAL SYNTHESIS OF MANNICH BASES IN SOLUTION/POLYMER REAGENT WORKUP  

作　　者：HUANG Wenqiang CHENG Shaoling CHEN Yu SUN Weimin HE Binglin 

机构地区：[1]Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China

出　　处：《Chinese Journal of Reactive Polymers》2000年第2期169-173,共5页中国反应性高分子（英文版）

基　　金：National Natural Science Foundation of China (29674915, 29844001).

摘　　要：This paper describes a combinatorial Synthesis of the Mannich Bases in Solution through the Mannich reaction using 3 ketones, 5 amines and formaldehyde in solution and hydrochloride as a catalyst and then using a macroporous quarterized ammonium resin (CO32- form) as a scavenge agent to remove the acid catalyst when the Mannich reaction is completed. It was found by GC/MS analysis that the symmetrical ketone, such as acetone, in the Mannich reaction mainly produces one Mannich base; while the asymmetrical ketone, such as 2-pentanone, gives two Mannich bases. The reactivity depends on the tereo-hinder of both ketones and amines.This paper describes a combinatorial Synthesis of the Mannich Bases in Solution through the Mannich reaction using 3 ketones, 5 amines and formaldehyde in solution and hydrochloride as a catalyst and then using a macroporous quarterized ammonium resin (CO32- form) as a scavenge agent to remove the acid catalyst when the Mannich reaction is completed. It was found by GC/MS analysis that the symmetrical ketone, such as acetone, in the Mannich reaction mainly produces one Mannich base; while the asymmetrical ketone, such as 2-pentanone, gives two Mannich bases. The reactivity depends on the tereo-hinder of both ketones and amines.

关 键 词：Combinatorial Synthesis in Solution Mannich reaction Mannich Bases macroporous quarterized ammonium resin Scavenge Resin$ 

分 类 号：TQ322.4[化学工程—合成树脂塑料工业]