补肾方对水杨酸模型大鼠甲状腺激素和睾酮的作用  

Effects of kidney tonic herbs on the levels of testosterone and thyroid hormone in serum of the salicylate model rats

作　　者：王静[1] 施建蓉[1] 郭瑞新[1] 曾兆麟[1] 方军[2] 

机构地区：[1]上海中医药大学生理教研室,200032 [2]上海中医药大学同位素室

出　　处：《中国中西医结合耳鼻咽喉科杂志》2003年第1期5-7,共3页Chinese Journal of Otorhinolaryngology in Integrative Medicine

摘　　要：目的探讨补肾方改善水杨酸所致耳鸣作用的可能机理。方法成年Wistar大鼠饮用含水杨酸水4周,分设水杨酸模型组、中药防治组、西药防治组及正常饮水之对照组,检测各组血清性激素(T)、甲状腺激素(T3、T4)。结果与对照组相比,水杨酸模型组的T4比对照组有显著降低,中药与卡马西平治疗组均显示出明显的治疗作用,其水平明显回升(P<0.05)。水杨酸模型组的T、T3有下降趋势。结论 补肾方对水杨酸模型大鼠下丘脑-垂体-甲状腺及性腺轴功能的调节可能是其改善水杨酸所致耳鸣的作用途径之一。Objective To investigate the possible mechanism of kidney tonic herbs (KTH) to ameliorate salicylate-induced tinnitus. Methods Wistar rats were chronically treated with sai-icylate(SA) water. Then, they were divided into SA modeling group and treating group treated by KTH and carbamazepine respectively. The level of testosterone (T) and thyroid hormone (T3, T4) in serum were determined before and after treatment, comparing with the control group with SA-free drinking water. Results Compared with control group. SA modeling group had significantly decreased levels of T4 in serum, and KTH and carbamazepine groups showed significantly elevated levels of T4(P<0. 05). Conclusion The regulating effect of kidney tonic herbs on the function of hypothalamus-hypophysis-thyriod and sexual gland axises may be one of the mechanisms to ameliorate salicylate-induced tinnitus.

关 键 词：补肾方 水杨酸模型 大鼠 甲状腺激素 睾酮 耳鸣 

分 类 号：R285.5[医药卫生—中药学] R764.45[医药卫生—中医学]