不同透皮促进剂对环吡酮胺和水杨酸体外经皮渗透性的影响  

Effects of different penetration enhancer on penetration of ciclopirox olamine and salysic acid in percutaneous penetration

作　　者：冯小龙[1] 王晖[1] 朱慧明[1] 

机构地区：[1]广东医学院药理教研室,广东湛江524023

出　　处：《中国临床药理学与治疗学》2003年第1期67-70,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：广东省教育厅资助项目 (GK0 10 3)

摘　　要：目的 :以环吡酮胺和水杨酸为模型药物 ,研究透皮促进剂对外用抗真菌药的促透特性。方法 :在离体透皮实验装置上进行透皮吸收试验和贮库效应的研究。结果 :1%氮酮和 1%薄荷醇联用对环吡酮胺经皮渗透的促进作用明显高于其它组 ,1%的薄荷醇对水杨酸促透效果最佳 ,而由 1%氮酮、2 .5 %丙二醇、2 .5 %油酸、1%薄荷醇合用对环吡酮胺的体外经皮渗透虽具有明显的促进作用和时滞明显缩短 ,但是与二联使用透皮促进剂比较并无明显优点。结论 :薄荷醇和氮酮对环吡酮胺和水杨酸体外经皮吸收具有显著的促进作用 ,两者联用对脂溶性化合物环吡酮胺的促透作用更明显。AIM: To study the enhancing effect of penetration enhancer on percutaneous absorption of antifungal agents. METHODS: Percutaneous penetration experiment was performed on device in vitro, and the deposit effects were observed with vivoperception. RESULTS: Combination of 1-menthol (1%) and azone (1%) showed the best effect on percutaneous absorption of cidopicox olamine, and 1-menthol (1%) had the best effect on percutaneous absorption of salysic acid. The compound penetration enhancer, consisting of 1-menthol (1%), azone (1%), propylene glycol ( 2.5%) and oleic acid ( 2.5%), had prominent action on absorption of cidopirox olamine through rabbit skins, and shorten the lag times obviously. CONCLUSION: L-menthol and azone can significantly enhance the percutaneous absorption of both salysic acid and cidopicox olamine. Combination of 1-menthol and azone can further increase the absorption.c

关 键 词：药理学 药物联用 离体透皮吸收试验 透皮促进剂 水杨酸 环吡酮胺 贮库效应 

分 类 号：R978.5[医药卫生—药品]