银杏叶聚戊烯醇抗癌作用的初步研究  

A Preliminary Study of Antitumor Effects of Polyprenols Extracted from Folium Gingko

作　　者：高凌[1] 亢寿海[1] 张琴芬[1] 张能芳[1] 钱新华[1] 徐荣华[1] 

机构地区：[1]江苏省肿瘤防治研究所,南京210009

出　　处：《江苏药学与临床研究》2003年第1期1-3,共3页Jiangsu Pharmacertical and Clinical Research

基　　金：江苏省科技厅社会发展项目资助 (BS2 0 0 10 6 5)

摘　　要：目的 :研究银杏叶 (FoliumGinkgo)提取物—聚戊烯醇 (PolyprenolsGP 1 )的抗肿瘤作用。方法 :采用动物抗移植性肿瘤实验方法。结果 :1 0 0mg/kg的聚戊烯醇对移植性肝癌Heps和肉瘤S1 80 的实验抑制率分别为 49 1 3 %和 46 53% ,40 0mg/kg的聚戊烯醇对艾氏癌EC抑制率为 49 65 % (P <0 0 1 )。银杏叶聚戊烯醇对艾氏腹水癌EAC小鼠无明显延长寿命作用。结论 :银杏叶聚戊烯醇有良好的抗肿瘤作用 。Objective:to study the effects of Polyprenols (GP 1),an extract of Folium Gingko , on tumor Methods:Using grafting tumor models in mice to detect the inhibitory rates Results:The inhibitory rates were 49 13% and 46 53% on Heps and S 180 respectively when GP 1 was given orally at the dose of 10 0mg/kg;And the inhibitory rate was 49 65% on EAC at the dose of 40 0mg/kg,but GP 1 had no effect of prolonging lifespan Conclusion:GP 1 had significant antitumour effects,it's worthy to do some additional research

关 键 词：聚戊烯醇 抗肿瘤 HEPS S180 EAC 

分 类 号：R965.2[医药卫生—药理学]