抑毒调平液抗乙型肝炎病毒体外实验研究  

STUDY ON ANTI-HBV ACTIVITY OF YIDUTIAOPINGYE IN VITRO

作　　者：李莉 唐坤华[2] 余光开[2] 王明勇[2] 邓存良[2] 刘玉华[3] 刘薇[2] 

机构地区：[1]解放军第四五二医院感染病科,四川成都610021 [2]泸州医学院感染病科 [3]中南大学湘雅二院

出　　处：《泸州医学院学报》2003年第1期12-14,共3页Journal of Luzhou Medical College

摘　　要：目的 :研究抑毒调平液在 2 .2 .15细胞培养中抗乙型肝炎病毒 (HBV)作用。方法 :用 2 .2 .15细胞体外培养 ,对抑毒调平液抗HBV活性进行评价。结果 :抑毒调平液对 2 .2 .15细胞HBsAg和HBeAg分泌的抑制率分别在19.6 4 %～ 5 7.93%和 2 1.31%～ 6 0 .2 2 %之间 ,该抑制呈剂量依赖性。药物对HBsAg、HBeAg的治疗指数分别为 3.2 7、3.6 4。药物处理的 2 .2 .15细胞培养上清液HBVDNA量明显降低 ,亦呈剂量依赖性。结论 :抑毒调平液在体外细胞培养中对HBsAg、HBeAg及HBVDNA的分泌均有较好的抑制作用。Objective: To study the anti-HBV activity of YiDuTiaoPingYe(YDTP) on cultured 2.2.15 cells. Methods: Using 2.2.15 cells to conduct external culture, and evaluate activity of YDTP restraining HBV. Results: The inhibitory rates of YDTP on HBsAg/HBeAg expression of 2.2.15 cells were 19.64%～57.93% and 21.31%～ 60.22% respectively. The inhibition was in a dose-dependent manner. TI(therapy index) was 3.27, 3.64 on HBsAg and HBeAg respectively. The amount of HBV DNA in the supernatant of 2.2.15 cells cultured with YDTP decreased obviously and dose-dependently. Conclusion: The data indicate that YDTP has a stronger inhibitory effect on secretion of HBsAg, HBeAg and HBV DNA in 2.2.15 cell culture.

关 键 词：抑毒调平液 体外细胞培养 抗HBV活性 中药制剂 

分 类 号：R285.5[医药卫生—中药学]