中国农村地区人群吸烟状态与血脂的相关性分析  

Association of smoking with serum lipid of rural areas of China

作　　者：丁昱[1] 罗静[1] 崔伟[1] 王滨燕[2] 唐根富[1] 臧桐华[1] 秦献辉[2] 汪月娟[3] 李幼宝[3] 张湘林 张岩[4] 李建平[4] 霍勇[4] 徐希平[1] 

机构地区：[1]安徽医科大学生物医学研究所,安徽合肥230032 [2]南方医科大学南方医院国家肾脏临床医学研究中心,广东广州510515 [3]南方医科大学南方医院肾内科,广东广州510515 [4]北京大学第一医院心内科,北京100034

出　　处：《中华疾病控制杂志》2015年第6期559-563,共5页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(81473052)

摘　　要：目的探讨中国农村地区人群吸烟状态与血脂的关系及其影响因素。方法 2008年5月在安庆及连云港农村地区进行流行病学调查,通过问卷收集研究对象的吸烟状况以及其他相关信息,实验室检查血总胆固醇(total cholesterol,TCHO)、甘油三酯(triglyceride,TG)、高密度脂蛋白(high density lipoprotein,HDL),通过Friedewald公式计算低密度脂蛋白(low density lipoprotein,LDL),采用多元线性回归来估计吸烟与血脂指标的关联。结果 26 516名研究对象纳入分析,其中男性10 066人(38.0%)。调整年龄、地区、体质指数、饮酒后,男性当前吸烟者的甘油三酯(β=0.37,sx珋=0.16,P=0.020)显著高于、高密度脂蛋白(β=-0.26,sx珋=0.08,P<0.001)显著低于不吸烟者,女性当前吸烟者的总胆固醇(β=1.28,sx珋=0.46,P=0.005)和低密度脂蛋白(β=1.15,sx珋=0.41,P=0.006)显著高于不吸烟者。按年龄分层,吸烟与血脂的关系主要见于高年龄段,低年龄时未见吸烟与血脂显著相关。结论吸烟与血脂存在关联,吸烟者的血脂高于不吸烟者,吸烟与血脂的关系在高年龄人群中较为明显。Objective To examine the relationship between smoking and serum lipid,and to find its potential interference in China's rural areas.Methods An epidemiological investigation was conducted in Anqing and Lianyungang rural areas in May,2008.Standardized questionnaire investigations were used to collect information on health,smoking and other factors.Serum total cholesterol,triglyceride and high density lipoprotein cholesterol were measured in National Kidney Clinic Center and low density lipoprotein cholesterol was calculated using Friedewald equation.Association between smoking and serum lipid were estimated using multiple linear regression.Results A total of 26 516 participants were included in the data analysis,and 10 066( 38.0%) were males.After adjusted for age,body mass index,region and alcohol use,serum triglyceride( β = 0.37,sx-= 0.16,P = 0.020) was significantly higher and high density lipoprotein( β =-0.26,sx-=0.08,P = 0.001) was significantly lower in male current smokers than in non-smokers.Serum total cholesterol( β = 1.28,sx-= 0.46,P = 0.005) and low density lipoprotein( β = 1.15,sx-= 0.41,P = 0.006) were significantly higher in female current smokers than in non-smokers.Serum triglyceride was significantly higher in male used to be smokers than in nonsmokers.After stratified by age,the association between cigarette smoking and serum lipid was significant only in the elderly group.Conclusions Serum lipid is higher in smokers than in non-smokers,and the association of smoking with serum lipid is remarkable in elderly.

关 键 词：农村卫生 吸烟 流行病学方法 

分 类 号：R195[医药卫生—卫生统计学]