参附注射液的微循环作用研究  

Effect of Shenfu Injection on Microcirculation

作　　者：杨芳炬[1] 郑有顺[2] 李东晓[3] 邓文龙[3] 

机构地区：[1]四川大学基础医学与法医学院,成都610041 [2]第一军医大学,广州510280 [3]四川省中药研究所,成都610041

出　　处：《生物医学工程学杂志》2003年第1期91-94,100,共5页Journal of Biomedical Engineering

摘　　要：观察参附注射液对各种微循环状态的影响。用微循环显微分析系统观察给予参附注射液的小鼠耳廓微动脉在各种状态 (正常状态、肾上腺素或内毒素导致循环障碍状态 )下的直径、毛细血管交叉网点数及血流速度 ,并与生理盐水对照组、参麦组、地塞米松组的上述指标进行比较。结果表明 ,参附注射液均使各种状态下的小鼠耳廓微动脉直径扩大 ,毛细血管交叉网点数及血流速度增加 ;其中对肾上腺素、内毒素所致外周循环障碍作用尤为显著 ;其作用较参麦注射液明显 ,与地塞米松作用相似 ;This study was aimed to assess the effect of Shenfu injection on different circulation state. Using a microcirculation microscope system,we observed mice's auricle micro-artery diameter, density of capillary , blood velocity in different circulation state(i.e.normal state, epinephrine or endotoxin induced microcirculation disturbance state) after administering Shenfu injection into their caudal vein, and we compared the Shenfu group with Shenmai group and Dexamethasone group. The results showed that Shenfu injection causes the auricle micro-artery diameter to enlarge and the density of capillary and blood velocity to increase in different microcirculation state, and such effect is especially notable on the epinephrine induced microcirculation disturbance group and endotoxin induced microcirculation disturbance group; the effect of Shenfu injection is stronger than that of Shenmai injection and similar to Dexamethasone injection. In addition, Shenfu injection was shown to have remarkable effect on resisting the lowering of limb temperature when the mice are attacked by endotoxin.

关 键 词：参附注射液 微循环作用 毛细血管交叉网点数 微动脉直径 血流速度 内毒素 

分 类 号：R285.5[医药卫生—中药学]