^(125)I-白细胞介素-8在小鼠体内的分布研究  

Study of ^(125)I-interleukin -8 Distribution in Mice

作　　者：范我[1] 钱建华[1] 朱然[1] 许玉杰[1] 张毅 朱本兴[1] 

机构地区：[1]苏州大学放射医学系,苏州215007

出　　处：《生物医学工程学杂志》2003年第1期95-96,共2页Journal of Biomedical Engineering

摘　　要：为了解白细胞介素 - 8的体内行为 ,用 Bolton- Hunter法对 IL- 8进行 1 2 5I标记 ,并测定它在小鼠体内的分布 ;得到了 1 2 5I- IL- 8在小鼠血、心、肝、肺、肾、骨、脾等脏器中的分布以及它在血液中的快相半排期 T1 /2α为 0 .3 2 h和慢相半排期 T1 /2β为 8.0 1h。1 2 5I- IL-IL-8 was radiolabeled with 125I via Bolten-Hunter agent and the distribution of 125I- IL-8 in mice was determined in order to understand IL-8 behaviors in vivo. The percentage of 125I- IL-8 in blood, heart, liver, lung, kidneys, bone and spleen was obtained. The half-clearance of fast phase T 1/2α and slow phase T 1/2β were 0.32 h and 8.01 h respectively. Most of 125I- IL-8 was excluded by kidneys.

关 键 词：^125I-白细胞介-8 小鼠 体内分布 血液消除 

分 类 号：R392[医药卫生—免疫学]