肾阳虚型大鼠子宫发育不良模型的建立及其特征研究——子宫组织形态学特性研究  

Establishment of Animal Model of Hyp orephreyang's Hypoplasia of Uterus and Research on Its Characteristics---researth on the form and microstructure characteristics

作　　者：范扶民[1] 陈晓钟[1] 

机构地区：[1]唐山工人医院,河北唐山063000

出　　处：《山西中医学院学报》2003年第1期11-13,共3页Journal of Shanxi College of Traditional Chinese Medicine

摘　　要：目的:建立肾阳虚子宫发育不良动物模型,进行子宫组织形态观测。方法:将36只雌性大鼠随机分为4组。A组:空白组,8只;B组:地塞米松加假手术组,9只;C组:卵巢切除加地塞米松组,9只;D组:卵巢切除加地塞米松加右归丸组,10只。实验25d后处死大鼠,称取子宫重量并测定子宫内膜、肌层厚度,观察内膜组织结构。结果:子宫重量、内膜、肌层厚度D组与A组比较无显著差异(P>0.05),C组与D组比较差异显著(P<0.05);子宫组织结构C组细胞分化不良,D组明显改善。结论:卵巢切除加地塞米松可建立肾阳虚子宫发育不良动物模型;右归丸不仅可改善动物模型一般行为学表现,而且具有类性激素样作用,促进大鼠子宫发育。Objective:To establish the model of hyporephre yang' s hypoplasia of uteru s and to observe the histological morphology.Methods:36(SD)female rats wer e randomly divided in to 4groups .A group:va-cancy group of 8rats;B group :Dexame (Dex)+Sham group of 9rats;C group:ovariectomizde(OVX)+Dex grou p of 9rats;D group:OVX +Dex treated with Yougui wan group of 10rats.Twent y-five days later,kill the anmals and measure the weight of u terus,The thic kness of uterine endometrial and muscle observe the form and microstructure of u terine e ndometrial.Results:In contrast with vacancy group,OVX +Dex +Yougui wan group showed no significa nt difference in their weight of uterus,the thick ness of uterine en-dometrial and muscle(P>0.05),but there was significa nt difference between OVX +Dex group and OVX +Dex +Youguiwan group(P<0.0 5);The form and microstructure of uteru s of OVX +Dex +Youguiwan group was better than that of OVX +Dex group.Conclusion:The model of hyporephreyang' s hypoplasia of uterus could be made with OVX +Dex;Youguiwa n not only could cha nge the behaviour of hypone phreyang ani-mal' s model but also could improve u terin e growth due to its function of sex-hormone.

关 键 词：肾阳虚 子宫发育不良 形态结构 右归丸 

分 类 号：R271.911[医药卫生—中西医结合]