补肾活血泄浊汤抗大鼠微小病变肾病脂质过氧化损伤的研究  

The Influence of Decoction of Bushenhuoxuexiezhuo on Lipid Peroxidation and Superoxide Dismutase in Minimal Change Nephropathy in Rat

作　　者：张悦[1] 魏民[2] 王谦[2] 楚非[3] 

机构地区：[1]上海中医药大学,上海200032 [2]北京中医药大学,北京100029 [3]美国伊利诺伊州立大学,诺默尔61761

出　　处：《中国中西医结合肾病杂志》2003年第3期139-140,共2页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：国家自然科学基金资助项目 (No .3 95 70 893 )

摘　　要：目的 :探讨补肾活血泄浊汤对阿霉素所致大鼠微小病变肾病脂质过氧化损伤的影响。方法 :采用阿霉素致大鼠微小病变肾病模型。治疗组灌服中药复方补肾活血泄浊汤 ,正常组和模型组灌服生理盐水。观察中药复方对肾组织匀浆超氧化物歧化酶 (SOD)、丙二醛 (MDA)含量、肾功能及肾脏病理损伤的影响。结果 :治疗组的尿蛋白、血清胆固醇、血清白蛋白以及肾组织SOD、MDA、病理形态的改变均较模型组为轻。结论 :补肾活血汤是通过升高血清白蛋白、降低血清胆固醇、改善肾组织活性、氧清除酶活性而发挥其治疗作用。Objective:To investigate the mechanism of Decoction of Bushenhuoxuexiezhuo (BSHXXZ decoction) on lipid peroxide in rats with nephrotic syndrome.Methods:A rat model of minimal change nephropathy(MCN)induced by adriamycin(ADR)was used in this study.Rats were divided into two groups:group 1 was treated with BSHXXZ decoction,group 2 treated with normel saline.In addition,normal rats were used as control.24 h urine protein excretion rate,albumin,cholesterol in serum,and malondialdehyde(MDA),superoxide dismutase(SOD),pathological changes of kidneys were observed. Results :Urine protein,cholesterol in serum,MDA in kidney homogenates decreased,while serum albumin,SOD in renal parenchyma increased ( P <0.05)in treatment group compared with model group. Conclusion:BSHXXZ decoction has therapeutic effect on rat MCN induced by ADR,probably related to decrease serum lipids level and reduce oxygen free radicals.

关 键 词：微小病变肾病 脂质过氧化损伤 补肾活血泄浊汤 

分 类 号：R285.5[医药卫生—中药学]