硝苯地平海藻酸钙凝胶缓释微丸体外释药特征研究  

In-vitro Dissolution of Nifedipine Ca-alginate Gel Sustained-release Pellets

作　　者：徐超斗[1] 雷宁[2] 曹淼[2] 马萍[2] 孙淑英[3] 

机构地区：[1]总后勤部卫生部药品仪器检验所,北京100166 [2]第二炮兵总医院药学部,北京100088 [3]沈阳药科大学药学院,辽宁沈阳100016

出　　处：《解放军药学学报》2015年第5期384-386,共3页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的研究硝苯地平海藻酸钙凝胶缓释微丸的制剂学特点。方法以硝苯地平为模型药,采用滴制法制备海藻酸钙凝胶缓释微丸,考察其体外释药特征,并进行物相分析和制剂稳定性试验。结果海藻酸钙凝胶微丸中药物的释放受介质p H值的影响,硝苯地平在微丸中以结晶形式存在,制剂在室温避光条件下稳定。结论硝苯地平海藻酸钙凝胶缓释微丸体外具有较好的缓释效果,有进一步研发的价值。Objective To investigate the pharmaceutical characteristics of nifedipine Ca-alginate gel sustained-release pellets. Methods Ca-alginate gel beads that contained the model drug nifedipine were prepared by dropping method. The dissolution character in-vitro was studied while physics phase analysis and stability test were conducted. Results The release of nifedipine in Ca-alginate gel pellets was affected by p H of the medium,the form of nifedipine in pellets was crystalline,and the preparation was stable at room temperature,away from light. Conclusion Nifedipine Ca-alginate gel sustained-release pellets have good sustained-release effect in-vitro,worthy of further research.

关 键 词：硝苯地平 海藻酸钙 凝胶微丸 缓释制剂 物相分析 稳定性试验 

分 类 号：R961[医药卫生—药理学]