缬沙坦对原发性高血压患者左室肥厚逆转作用  

Effect of valsartan on left ventricnlar hypertrophy in patients with essenticel hypertension

作　　者：苏光[1] 袁德琴[1] 张海燕[1] 王慧霞[1] 陈树杰[1] 阎晓虹[1] 

机构地区：[1]邯郸市第二医院心内科,河北邯郸056001

出　　处：《临床心血管病杂志》2003年第2期98-99,共2页Journal of Clinical Cardiology

摘　　要：目的 :研究缬沙坦对原发性高血压 (EH)患者的降压作用和对左室肥厚 (LVH)的影响。方法 :选择5 2例EH患者 ,其中有LVH者 2 0例 ,口服缬沙坦 80～ 16 0mg/d ,为期半年。观察血压、不良反应 ,治疗前后测血脂、血糖和肝肾功能 ,并作二维超声心动图检测 ,采用自身前后对照的实验方法。结果 :EH患者经缬沙坦治疗后收缩压、舒张压显著下降 (P <0 .0 1) ,其中LVH者治疗后左心室舒张末期内径及左室重量均明显下降 (P <0 .0 5 ) ,舒张末期左室后壁厚度、室间隔厚度及左室重量指数下降更明显 (P <0 .0 1)。结论 :缬沙坦治疗EH安全、有效 ,并且可逆转LVH。Objective:To study the effect of valsartan on left ventricular hypertrophy in patients with essenticel hypertension.Methods:The study population consisted of 52 essenticel hypertensive patients, 20 patients with left ventricular hypertrophy. All patients received valsartan 80～160 mg per day for half year. Left ventricular diameter and left ventricular mass index were measured by echoardiography.Results:The valsartan significantly decreased systolic blood pressure, diastolic blood pressure in patients with essential hypertension (P< 0.01 ) . For the patients with left ventricular hypertrophy, valsartan reduced both left ventricular end diastolic diameter and left ventricular mass (P< 0.05 ). Meanwhile it were obviously improved for diastolic left ventricular posterior wall thickness, ventricular septum thickness and left ventricular mass index (P< 0.01 ).Conclusion:Valsartan is a effective drug to reverse left ventricular hypertrophy.

关 键 词：缬沙坦 高血压 左心室肥厚 超声心动描记术 

分 类 号：R972[医药卫生—药品] R544.1[医药卫生—药学]