食物过敏后肠道通透性的研究  

Changes in the intestinal permeability of food allergy

作　　者：陈虹[1] 陈奋华[1] 李银涛[2] 纪经智[1] 何政贤[1] 王清文[1] 饭仓洋治 

机构地区：[1]中山大学附属第三医院儿科,广东广州510630 [2]中山大学附属第三医院皮肤科,广东广州510630 [3]日本东京昭和大学医学部儿科系,日本东京1420064

出　　处：《免疫学杂志》2003年第2期140-141,145,共3页Immunological Journal

摘　　要：目的　研究食入过敏原后 ,不同时相下的肠道黏膜通透性变化。方法　将卵蛋白 (OVA)致敏大鼠分成 3组 ,分别以OVA(2mg/mL)经肠道攻击 1、6和 2 4h后经口投用β乳球蛋白 (BLG) 5mg/mL ,2h后采血 ,用ELISA法测定血清中BLG的浓度 ,并对小肠黏膜浸润炎性细胞计数分类。结果　 3组实验大鼠血清BLG浓度与对照组比较均增高 ,P值有显著差异 (P <0 .0 1) ;实验组间血清BLG的质量浓度比较无显著差异 (P >0 .0 5 ) ,且实验组大鼠小肠黏膜内浸润的炎性细胞种类因食入后时相不同而有差异。结论　在食物过敏反应中 ,不论速发型或迟发型变态反应 ,肠道的通透性均增加 。Objective To study the change of intestinal permeability dur ing different times after ingesting food allergen.Method Experi mental rats sensitized using OVA were divided into three groups, then administer ed BLG orally,1, 6 and 24 hours after challenged with OVA orally. The levels of serum BLG were measured using ELISA. At the same time, the authors also analyzed intestinal histopathology. Results Levels of serum BLG in s ensi tized rats were increased significantly as compared with that of control group. But there were no diffe rence among three groups sensitized with OVA. Infla mmator y cells varied in different times after challenged with OVA.Conclusion During food allergy, intestinal permeability was not increased in the im mediate IgE dependent phase, but in a late or delayed phase. [

关 键 词：食物过敏 肠道通透性 变态免疫性反应 肠道黏膜通透性 

分 类 号：R392[医药卫生—免疫学]