人体血浆中Tb(Ⅲ)物种的计算机模拟研究(英文)  

Computer Simulation of Tb(Ⅲ) Speciation in Human Blood Plasma

作　　者：卢兴[1] 张海元[1] 王进平[1] 王悦[1] 杨魁跃[1] 牛春吉[1] 倪嘉缵[1] 

机构地区：[1]中国科学院长春应用化学研究所稀土化学与物理开放实验室,长春130022

出　　处：《中国科学院研究生院学报》2003年第1期7-12,共6页Journal of the Graduate School of the Chinese Academy of Sciences

基　　金：supportedbyNationalNaturalAcienceFoundationofChina(2 9890 2 80;2 99710 2 9)

摘　　要：建立了人体血浆多相模型,研究了人体血浆体系中Tb(Ⅲ)物种的分布。结果表明,Tb(Ⅲ)的物种形式随着Tb(Ⅲ)的量浓度的变化而变化。当Tb(Ⅲ)的量浓度低于 4.0 0 0× 1 0 - 8mol/L时,大部分Tb(Ⅲ)物种以可溶态存在;当Tb(Ⅲ)的量浓度高于 4.0 0 0× 1 0 - 8mol/L而低于 1.667× 1 0 - 2 mol/L时,沉淀物种(TbPO4和Tb2 (CO3)3)成为Tb(Ⅲ)的主要物种。可溶的Tb(Ⅲ)在量浓度低于 1.0× 1 0 - 4 mol/L时,主要与运铁蛋白键合,分布于[Tb(Tf)]中;当Tb(Ⅲ)的量浓度高于 1.0× 1 0 - 4 mol/L时,运铁蛋白耗尽,可溶的Tb(Ⅲ)主要分布于[Tb(HSA)],[Tb2 (Tf)],[Tb(Ox)]和 [Tb(Cit)A multi phase model of human blood plasma was developed and the Tb(Ⅲ) speciation in this system was studied. The results show that the speciation of Tb(Ⅲ) depends on the concentration of Tb(Ⅲ). When the concentration of Tb(Ⅲ) is below 4.000×10 -8 mol/L, most of Tb(Ⅲ) exists as soluble species while the concentration of Tb(Ⅲ) is in between 4.000 ×10 -8 mol/L and 1.667×10 -2 mol/L, precipitates(TbPO 4 and Tb 2 (CO 3 ) 3 ) are the dominant species of Tb(Ⅲ). Among soluble Tb(Ⅲ) species, Tb(Ⅲ) is mostly bound to the transferrin to form \ when the concentration of soluble Tb(Ⅲ) is below 1.0×10 -4 mol/L. The concentration of soluble Tb(Ⅲ) reaches 1.0×10 -4 mol/L, thus available transferrin is exceeded, and soluble Tb(Ⅲ) ions mainly distribute in \, \[Tb 2 (Tf)\], \ and \ etc.

关 键 词：计算机模拟 物种分布 人体血浆 TB 铽 量浓度 可溶态 运铁蛋白 

分 类 号：R446.112[医药卫生—诊断学] TP391.9[医药卫生—临床医学]