变温含血停跳液间断顺灌的心肌保护作用  

Myocardial Protection of Changing Temperature Antegrade Intermittent Blood Cardioplegia

作　　者：陈干[1] 万于华[1] 饶华庚[1] 

机构地区：[1]江西医学院第一附属医院胸外科,江西南昌330006

出　　处：《江西医学院学报》2002年第5期65-67,共3页Acta Academiae Medicinae Jiangxi

摘　　要：目的 :探讨变温含血停跳液对重症心脏瓣膜置换的心肌保护作用。方法 :连续观察 2 0例瓣膜置换手术 ,并随机分为晶体组 10例和含血组 10例 ,晶体停跳液的温度为 4～ 8℃ ,含血停跳液的温度为 8～ 35℃不等。分别间断顺灌冠状动脉 ,达到心电图呈直线。从临床效果、心肌生化 (CK、CK MB)评价两种方法的心肌保护作用。结果 :含血组在体外循环时间和主动脉阻断时间显著延长的情况下 ,两组术后自动复跳率、起博心律出现率、CK、CK MB峰值相比均无显著差异。结论 :在体外循环心脏瓣膜置换手术中 。Objective: To evaluate the myocardial protection of changing temperature blood cardioplegia for heavy valve replacement. Methods: 20 valve replacement were divided into two groups randomly: Group cold(4～8℃)crystal cardioplegic (10 cases) and group changing temperature(8～35℃)blood cardioplegic(10 cases). Intermittent perfused coronary artery and induced until the ECG showed a straight line. The effect of myocardial protection of the two cardioplegic induction were evaluated by clinical outcome, myocardial biochemistry index (CK,CK-MD).Results:The ratio of myocardial auto-resuscitation, the ratio of used interim pacemakers and peak values of CK,CK-MD were not significantly higher in the two group in the case that the time of cardiopulmonary bypass(CPB)and the time of aortic unclamping in the group of blood cardioplaegic was significantly longer. Conclusion: Different temperature blood cardioplegic during valve replacement CPB can provide better myocardial protection than cold blood cardioplaegic.

关 键 词：体外循环 心肌保护 含血停跳液 

分 类 号：R654.1[医药卫生—外科学]