脑出血与脑梗死患者血脂和血清脂蛋白谱的比较  

Comparative study of serum lipids and serum lipoprotein spectrum in patients with cerebrovascular diseases

作　　者：周娟[1] 张暋[1] 李小敏[2] 

机构地区：[1]第一军医大学中医系,广东广州510515 [2]第一军医大学珠江医院中医科,广东广州510515

出　　处：《第一军医大学学报》2003年第3期262-264,共3页Journal of First Military Medical University

摘　　要：目的观察脑出血与脑梗死患者血脂和血清脂蛋白谱的变化及其特点。方法选择脑出血患者59例、脑梗死患者21例以及健康对照30例,测定血清甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDLC)、极低密度脂蛋白胆固醇(VLDLC)和低密度脂蛋白胆固醇(LDLC),并用改良双梯度聚丙烯酰胺凝胶电泳法测定了血清脂蛋白谱(SLPG)。结果脑梗死组TC、LDLC高于对照组,脑出血组LDLC高于对照组,低于脑梗死组;SLPG结果显示脑梗死组α脂蛋白(αLP)、β脂蛋白(βLP)、中间β脂蛋白(intβLP)高于对照组,脑出血组βLP、intβLP高于对照组,差别有统计学意义。逐步判别分析优选出βLP、intβLP、HDLC为判别脑血管病(CVD)的指标,这三项指标对CVD的判对率为71.3%。结论βLP、intβLP、HDLC可作为临床预测脑血管病的重要指标。Objective To investigate the differences of serum lipids and serum lipoprotein spectrum between patients with cerebral hemorrhage (CH) and cerebral infarction (CI), and study their features of expression in the 2 cerebral conditions. Method Serum levels of triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), very-low-den-sity lipoprotein cholesterol (vLDLC), low-density lipoprotein cholesterol (LDLC) and serum lipoprotein electrophoretoagram were determined in 59 CI and 21 CH patients as well as in 30 normal subjects. Results CI patients had higher levels of TC, LDLC, α-lipoprotein (αLP), β-lipoprotein (βLP) and intermediate-density β-lipoprotein (intβLP) than the normal subjects, and the CH patients had lower LDLC level than the CI patients. The CH patients had also higher levels of βLP, int βLP and LDLC than the normal subjects. Progressive regression analysis was performed and resulted in the selection of βLP, int βLP and HDLC as the best discriminators for cerebral vascular diseases, which were valid in classifying 71.3% of the cases includ-ed in this study. ConclusionβLP, intβLP and HDLC are important clinical indicators to predict cerebral vascular diseases.

关 键 词：脑出血 血液 脑梗死 脂蛋白类 分析 

分 类 号：R446.112[医药卫生—诊断学]