小儿结肠传输时间的检测及临床意义  

The measurement of colonic transit time in children and its clinical significance

作　　者：李萍 王宝西[2] 杨敏[2] 王茂贵[2] 

机构地区：[1]河北武警总队医院儿科 [2]第四军医大学唐都医院儿科,西安710038

出　　处：《中国实用儿科杂志》2003年第3期152-154,共3页Chinese Journal of Practical Pediatrics

摘　　要：目的　了解儿童结肠传输时间 (CTT)的正常值 ,并探讨促肠动力药对小儿功能性便秘 (FC)结肠传输时间的影响。方法　采用不透X线标记物测定 68例正常儿童及 2 8例FC患儿全CTT和分段结肠传输时间 ,对全CTT延长的便秘患儿 ,给予促肠动力药物西沙必利 0 2mg kg ,每日 2次 ,治疗 2周 ,停药后 1周复查CTT ,比较服药前后CTT的变化。结果　全CTT的正常值上限为 2 4h ,FC组全结肠及各节段结肠传输时间较对照组明显延长 (P <0 0 5 )。 2 8例FC患儿中 16例的全CTT延长 ,经治疗后平均全CTT由 (5 4 0 1± 3 2 3 )h缩短至 (19 63± 1 3 8)h(P <0 0 1) ,各节段结肠传输时间亦缩短。结论　不透X线标记物检查技术简单易行 ,结果可靠。促肠动力药能缩短FC患儿全结肠及各段结肠传输时间 。Objective To investigate colonic transit time (CTT) in normal subjects and evaluate the effect of prokinetic drug on the colonic transit time (CTT) on functional constipation in children.Methods Total and segmental CTT were measured in 68 healthy volunteers and 28 patients with functional constipation using radiopaque markers. Patients with prolonged total CTT received prokinetic drug of cisapride 0 2mg/kg,b.i.d.orally for 2 weeks and CTT was measured again a week after treatment.Results The maximum normal value of total CTT was 24h.The total and segmental colonic transit times in the constipation group were significantly prolonged than those in the control group (P<0 05).It was prolonged in 16 of 28 constipated patients.After prokinetic therapy the average total CTT was significantly shortened from (54 01±3 23)h to (19 63±1 38)h (P<0 01),the segmental CTT was also shortened significantly.Conclusions The technique to measure CTT is simple ,convenient and reliable.Prokinetic drug,which can reduce total and segmental CTT,is an effective interference in functional constipation of children.

关 键 词：结肠传输时间 儿童 功能性便秘 促肠动力药 

分 类 号：R725.746.2[医药卫生—儿科]