特发性血小板减少性紫癜患儿合并柯萨奇B组病毒感染的临床特点及分析  

The clinical characteristic and analysis of coxackievirus B infection in children with idiopathic thrombocytopenic purpura

作　　者：蔡柳新[1] 方凤[2] 周霖[2] 

机构地区：[1]江西省宜丰县人民医院儿科 [2]上海第二军医大学附属长海医院儿科,200043

出　　处：《中国实用儿科杂志》2003年第3期155-156,共2页Chinese Journal of Practical Pediatrics

摘　　要：目的　探讨特发性血小板减少性紫癜 (ITP)患儿合并柯萨奇病毒B组 (CVB)感染的临床特点。方法　对 44例ITP患儿做骨髓细胞学分类 ,同时进行CVB、巨细胞病毒 (CMV)、EB病毒、乙肝病毒 (HBV)检查及血常规动态观察。结果　ITP患儿合并病毒感染中CVB明显多于EB、CMV、HBV等 ,有CVB感染阳性与CVB感染阴性的ITP患儿比较 ,骨髓巨核细胞总数明显增高 (P <0 0 1) ,外周血血小板计数和平均血小板体积明显降低(均P <0 0 1)。Objective To study the clinical characteristic of coxsackievirus B(CVB) infection in children with idiopathic thrombocytopenic purpura(ITP).Methods Forty-four cases with ITP were divided into two groups:CVB(+) and CVB(-).we detected bone marrow aspiration and the peripheral smear.CVB-Ag,CVB-IgM,EBV-IgM,and HBV serum markers were examined using ELISA method.Results The CVB infection incidence in ITP was higher than EBV,CMV and HBV.The numbers of megakaryocytes in CVB(+) groups were obviously increased (P<0 01),the platelet count and mean platelet volume were obviously decreased(P001).Conclusions CVB can significantly inhibit PLT system in children with ITP.

关 键 词：特性性血小板减少性紫癜 柯萨奇B组病毒 儿童 

分 类 号：R725.954.6[医药卫生—儿科]