绝经后妇女血清骨代谢生化指标的变化及意义  

Seurm Bone metabolism indexes change in postmenopausal women

作　　者：陶耕[1] 蔡俊峰[1] 李永加[1] 

机构地区：[1]福建医科大学附属第二医院中心实验室,362000

出　　处：《福建医药杂志》2003年第1期26-27,共2页Fujian Medical Journal

摘　　要：目的　为了探讨绝经后妇女的骨代谢。方法　本文对 37例绝经后妇女及 2 7例正常对照组 ,测定血清 型前胶原羧基末端前肽 (PICP)、 型胶原羧基端吡啶并啉交联肽 (ICTP)、骨钙素 (BGP)、碱性磷酸酶(AL P)、钙 (Ca)、磷 (P)等骨代谢指标。结果　绝经后妇女 组血清 PICP结果明显低于对照组 (P<0 .0 1) ,ICTP结果明显高于对照组 (P<0 .0 0 1) ,BGP明显低于对照组 (P<0 .0 5 )。绝经后妇女 I组 ICTP结果明显高于对照组(P<0 .0 1)。绝经后妇女年龄与血清 PICP、ICTP、BGP具有相关性 ,骨形成指标 PICP、BGP与骨吸收指标 ICTP均有相关性。结论　表明了绝经后妇女骨吸收过程增加较为明显 。Objective To study of bone metabolism in postmenopausal women.Methods serum carboxy terminal propeptide of type I procollagen(PICP),carboxy terminal telopeptide of type I coiiagen(ICTP),bone giaprotein(BGP),alkaline phosphatase(ALP),Calcium(Ca),Phosphorus(P) were measured in 37 postmenopausal women and 27 controls.Results Serum PICP in postmenopausal women Ⅱ group was significantly lower in controls(P<0 01),BGP in postmenopausal women Ⅱ group was significantly lower in controls(P<0 05),ICTP in postmenopausal women Ⅱ group was significantly higher in controls(P<0 01).ICTP in postmenopausal women Ⅰ group was significantly higher in controls(P<0 01).postmenopausal women.serum PICP,ICTP and BGP was correlated with the years postmenopausal women.All correlated between the PICP,ICTP and BGP.Conclusion The results indicate that bone resorption and bone mass loss is incressed postmenopausal women.

关 键 词：绝经后妇女 I型前胶原羧基末端前肽 Ⅰ型胶原羟基吡啶并啉交联肽 骨代谢 

分 类 号：R711[医药卫生—妇产科学]