神经起步点产生的一种新型簇放电节律——阵发周期1节律  

A NOVEL BURSTING IN THE EXPERIMENTAL NEURONAL PACEMAKER,INTERMITTENT PERIOD1SPIKING

作　　者：古华光 任维[1] 杨明浩[1] 陆启韶[2] 

机构地区：[1]航天医学工程研究所,北京100094 [2]北京航空航天大学理学院,北京100083

出　　处：《生物物理学报》2002年第4期440-447,共8页Acta Biophysica Sinica

基　　金：科技部(2001CCA00700);国家自然科学基金(30270432)资助项目

摘　　要：实验中发现了神经起步点产生的一种新型的簇放电节律——阵发周期1节律。其特征如下:连续周期1放电与休止期(quiescence)轮流出现;非周期性, 连续放电持续期、连续放电次数以及休止期有较大变异性;位于周期1节律和静息状态之间。具有较长周期的伪单色噪声激励的FHN(FitzHugh-Nagumo)模型可以产生类似的阵发周期1节律。模型和实验中的阵发周期1节律的统计特征、变化规律和所处的参数区间相类似。这表明:阵发周期1节律是由与伪单色噪声类似的长时程振荡激励引起的。A novel bursting, intermittent period 1 spiking, was observed in the experimental neuronal pacemaker. It showed the characteristics as follows: First, its spike trains randomly transiting between continual period 1 spiking and intermittency. Second, the duration of the intermittency, the duration and the number of the continual period 1 spikes exhibited large variability, indicating that the firing pattern was not periodic. Last, it lay between period 1 spiking and at rest. Intermittent period 1 spiking similar to experiments was simulated in the FHN(FitzHugh-Nagumo) model driven by quasi-monochromatic noise (QMN) with a long basic period. The statistical character, the changing regularity and the parameter region of two intermittent period 1 spiking were similar. The results showed that the intermittent period 1 spiking might be induced by an oscillation similar to the QMN with a long basic period.

关 键 词：簇放电 阵发 自发放电 节律 动作电位间期 随机自共振 

分 类 号：Q424[生物学—神经生物学]