东北鹤虱中香豆素类对兔离体回肠的作用  

Effects of coumarin from LEG on contractivity in isolated rabbit ileum

作　　者：孟林[1] 尹勇强[1] 高建华[1] 周晶[1] 

机构地区：[1]天津医科大学药理教研室,天津300070

出　　处：《中草药》2003年第3期241-243,共3页Chinese Traditional and Herbal Drugs

基　　金：天津市自然科学基金项目 ( 0 0 36 0 85 11)

摘　　要：目的　观察东北鹤虱中香豆素类对兔离体回肠的作用及对钙离子的影响。方法　采用兔离体回肠标本 ,给予不同剂量香豆素 ( CM)及维拉帕米 ( Ver) ,观察对平滑肌收缩的影响。结果　 CM和 Ver可剂量依赖性地抑制乙酰胆碱 ( Ach)引起的回肠的收缩 ,非竞争性拮抗 Ca Cl2 所致回肠收缩 ,并对 Ach引起的第 1,2相收缩均有影响。结论　东北鹤虱中提取的香豆素类具有与 Ver相似的钙拮抗作用。Object To observe the effects of coumarin (CM) and Verapamil (Ver) on contractivity and its relationship with Ca 2+ in isolated ileal smooth muscle of the rabbits. Methods The effects of CM and Ver were observed in three doses by routine experimental methods in isolated rabbit ileal. Results CM and Ver inhibited the contraction of isolated ileal smooth muscle induced by acetylcholine and CaCl 2. The responses were a concentration-dependent and non-competitive manner. CM and Ver were effective against the initial and sustained peak induced by acetylcholine. Conclusion CM has a calcium-antagonistic effect which is similar to that of Ver.

关 键 词：东北鹤虱 香豆素类 维拉帕米 回肠平滑肌 

分 类 号：R285.5[医药卫生—中药学]