EFFECT OF HIGH-LIPID DIET ON GLOMERULAR MESANGIAL MATRIX IN ADRIAMYCIN-INDUCED NEPHROTIC RATS  

作　　者：宋红梅 李学旺 魏珉 朱传酉 

机构地区：[1]Department of Pediatrics Department of Internal Medicine, Peking Union Medical College Hospital, CAMS ＆ PUMC, Beijing 100730 [2]Division of Nephrology, Department of Internal Medicine, Peking Union Medical College Hospital, CAMS ＆ PUMC, Beijing 100730

出　　处：《Chinese Medical Sciences Journal》2002年第3期134-139,共6页中国医学科学杂志（英文版）

摘　　要：OBJECTIVE: To determine the effect of hypercholsterolemia induced by a high-lipid diet on glomerulosclerosis. METHODS: Twenty nephrotic syndrome (NS) Wistar rats administrated adriamycin (ADR) with a single intravenous dose of 5 mg/kg body weight, were divided into the standard and high-lipid chow groups. Another 20 weight-matched non-NS rats that received a vehicle alone were grouped as control. Urinary protein excretion and serum cholesterol were assayed; image analysis and techniques of pathology, immunohistochemistry, and molecular biology were used to determine morphological changes in glomeruli and the production of glomerular mesangial matrices in different groups. RESULTS: The serum total cholesterol level was significantly higher in rats with high-lipid chow in both non-NS [(2.2 +/- 0.3) g/L vs. (0.9 +/- 0.1) g/L, P

关 键 词：adriamycin  induced nephrosis high  lipid diet glomerular mesangial matrixObjective. To determine the effect of hypercholesterolemia induced by a high-lipid diet on glomerulosclerosis. Methods. Twenty nephrotic syndrome (NS) Wistar rats admin 

分 类 号：R589.2[医药卫生—内分泌]