+Gz暴露时间对大鼠记忆功能和行为的影响  

Effects of +Gz Exposure Time on Memory and Behavior in Rats.

作　　者：韦应波[1] 孙喜庆[1] 曹新生[1] 姚永杰[1] 冯岱雅[1] 杨长斌[1] 

机构地区：[1]第四军医大学航空航天医学系航空航天生物动力学教研室,陕西西安710032

出　　处：《航天医学与医学工程》2003年第1期19-23,共5页Space Medicine & Medical Engineering

基　　金：国家自然科学基金资助项目 (3 980 0 15 8)

摘　　要：目的探讨 +Gz暴露时间对大鼠记忆功能和行为的影响。方法 2 4只雄性SD大鼠随机分为对照组、+ 1 0Gz/3min组和 + 1 0Gz/5min组 3组 ,每组 8只。 +Gz暴露大鼠分别进行 + 1 0Gz/3min或 5min暴露 ,记录 +Gz暴露后不同时间大鼠记忆功能和行为的变化。结果与对照组比较 ,在暴露后即刻、1d、2d、4d及 6d时 + 1 0Gz/5min组大鼠正确率均显著降低 (P <0 .0 1 ) ,反应时均显著延长 (P <0 .0 1 ) ;与 + 1 0Gz/3min组比较 ,在暴露后 1d、2d、4d及 6d时正确率亦均显著降低 (P <0 .0 1 ) ,反应时亦均显著延长 (P <0 .0 1 ) ;中央格内停留时间在暴露后即刻较对照组和 + 1 0Gz/3min组显著延长 (P<0 .0 1 ) ;平衡能力在暴露后即刻及 2d时较对照组和 + 1 0Gz/3min组显著变差 (P <0 .0 1 ) ;+ 1 0Gz/3min组大鼠反应时仅在暴露后即刻和 2d时较对照组显著延长 (P <0 .0 1 )。结论 + 1 0Gz/3min暴露可引起大鼠暂时性记忆功能障碍和行为的改变 ,而 + 1Objective To explore the effect of +Gz exposure time on memory and behavior in rats. Method Twenty four male SD rats were randomly divided into control group(A),+10 Gz/3 min group(B) and +10 Gz/5 min group(C). Rats in group A and B were exposed to +10 Gz for 3 min or 5 min respectively. Changes of memory and behavior in rats were observed after +Gz exposure. Result As compared with control, percentage of right reflex decreased significantly and reaction time lengthened significantly immediately,1 d,2 d,4 d and 6 d after +10 Gz/5 min exposure (P<0.01); reaction time lengthened significantly immediately and 2 d after +10 Gz/3 min exposure (P<0.01). As compared with +10 Gz/3 min, percentage of right reflex decreased significantly and reaction time lengthened significantly at 1 d,2 d,4 d and 6 d after +10 Gz/5 min exposure (P<0.01). As compared with control and +10 Gz/3 min, time stayed in center grille lengthened significantly immediately after +10 Gz/5 min exposure (P<0.01); balancing function decreased significantly immediately and 2 d after +10 Gz/5 min exposure (P<0.01). Conclusion It is suggested that +10 Gz/3 min exposure may induce a provisional disturbance in memory function and a change in behavior in rats, and +10 Gz/5 min exposure may induce a sustained disturbance in memory function and an obvious change in behavior in rats.

关 键 词：+GZ 正加速度 记忆 行为 大鼠 

分 类 号：R852.21[医药卫生—航空、航天与航海医学]