获得性纯红细胞再生障碍性贫血的细胞免疫发病机制的研究进展  

The Advance of Research on Pathogenesis of Acquired Pure Red Cell Aplastic Anemia Caused by Cellular Immune Abnormalities

作　　者：代阳[1] 

机构地区：[1]四川大学华西医院血液科,成都610041

出　　处：《中国实验血液学杂志》2003年第1期105-108,共4页Journal of Experimental Hematology

摘　　要：纯红细胞再生障碍性贫血是以骨髓单纯红系造血衰竭或紊乱为特征的一组异质性疾病 ,分为先天性和获得性两类。细胞免疫介导的红系造血损伤可能是获得性纯红细胞再生障碍性贫血的主要发病机制。本文就近年来关于获得性纯红细胞再生障碍性贫血的T细胞异常、T细胞亚群改变。Pure red cell aplastic anemia (PRCA) is a group of heterogeneous disorders characterized by erythropoiesis failure or disorder of bone marrow function. PRCA can be classified as congenital and acquired types. The recent researches have shown that cellular immune abnormalities are main reasons to cause PRCA. This review will focus on the focus points: T lymphocytes abnormalities, change of T cell subset phenotypes, abnormality of cellular clonality,and effects of related cytokines in PRCA.

关 键 词：纯红细胞再生障碍性贫血 细胞免疫异常 T细胞亚群 细胞因子 

分 类 号：R556.5[医药卫生—血液循环系统疾病]