小学生接种国产酵母乙肝疫苗3年后免疫效果观察  

Observation on efficacy of yeast derived hepatitis B vaccines on vaccinated children in three years later

作　　者：时景璞[1] 陈祚[1] 郑力国 王桂花 徐占民 杨志奇 郭玉凤 杨俊山 吴晓音[4] 梁争论[4] 

机构地区：[1]中国医科大学第一临床医院临床流行病教研室,沈阳110001 [2]辽宁省北票市第二人民医院 [3]辽宁省北票市中小学卫生保健所体检科 [4]卫生部药品生物制品检定所疫苗二室

出　　处：《中国公共卫生》2003年第3期263-264,共2页Chinese Journal of Public Health

基　　金：国家"九五"攻关课题 (96 - 90 6 - 0 3 - 0 3)

摘　　要：目的　研究小学生接种酵母乙肝疫苗后的免疫效果。方法　在辽宁省北票市各小学校选择一般健康状况良好 ,HBsAg、抗 -HBs、抗 -HBc3项指标均为阴性 ,免前体温正常的 7～ 9岁儿童 ,随机抽取 110名 ,接种酵母乙肝疫苗。第一针免后 3 ,7,12 ,2 4,3 6个月采血检测抗 -HBs。结果　第一针免后各次采血检测抗 -HBs阳转率分别为75 7% ,10 0 0 % ,95 1% ,90 7%和 87 5 % ,其中 2 4个月时抗 -HBs阳转率女性显著高于男性 (P <0 0 5 )。抗 -HBs几何平均滴度 (GMT)分别为 43 78,40 2 92 ,170 43 ,15 5 49和 10 7 5 7mU/ml,各次结果显示男女之间抗 -HBs滴度无显著性差异。抗 -HBs滴度分布仅在T12 时男女之间有显著性差异 (P <0 0 5 ) ,其余各次结果均无显著性差异。结论　酵母乙肝疫苗接种儿童具有良好的安全性和免疫原性 。Objective To evaluate the immune efficacy and safety of yeast-derived hepatits B vaccines (YDV) on children.Methods One hundred and ten children aged 7 to 9 years old were randomly selected at some schools in Beipiao city,Liaoning Province,whose HBsAg,anti-HBs,anti-HBc were all negtive.They were vaccinated with YDV.Test serum anti-HBs at 3,7,12,24 and 36 months after the first dose YDV was vaccinated.Results Positive seroconvertion rates of anti-HBs were 75.7%,100.0%,95.1%,90.7% and 87.5%,respectively;positive seroconvertion rate of anti-HBs of the female was higher than that of the male (P<0.05) at 24 month(T 24).Mean geometric titres(GMT) of anti-HBs wer 43.78,402.92,170.43,155.49 and 107.57?mU/ml,respectively;The results indicated that GMT of anti-HBs reached its peak at 7 month(T\-7);the difference of the GMT of anti-HBs between the male and the female was not significant(P>0.05);the distribution of anti-HBs titre was significantly different(P<0.05) only at 12 month (T 12).Conclusion YDV was safety and immunogenic to vaccinate children.It was necessary to follow up these children to know how long the protective level could last.

关 键 词：酵母乙肝疫苗 小学生 免疫效果 抗体几何平均滴度 

分 类 号：R512.620.3[医药卫生—内科学]