动物饲料促生长剂对大鼠部分生殖功能指标的影响  

Effects of animal growth-promoter on rats' part of reproductive function

作　　者：李军[1] 李晓梅[1] 赵辉[2] 刘国庆[1] 于丽华[1] 郭冬梅[1] 

机构地区：[1]山东大学公共卫生学院,济南250012 [2]泰安出入境检验检疫局

出　　处：《中国公共卫生》2003年第3期313-314,共2页Chinese Journal of Public Health

基　　金：山东省自然科学基金资助项目 (Y2 0 0 1C30 )

摘　　要：目的　探讨动物饲料促生长素添加剂对雌性大鼠部分生殖功能的影响。方法　采用动物实验方法 ,研究不同浓度促生长剂溶液灌胃对大鼠阴道开口时间、动情周期、脏器系数等生殖功能指标和对肝脏毒性指标的影响。结果　 ( 1)低剂量组大鼠平均体重和体重增长率高于对照组 (P <0 0 5 ) ;( 2 )低剂量组大鼠阴道开口时间明显早于对照组 (P <0 0 5 ) ;( 3 )染毒 2周后低剂量组进入动情期的大鼠多于对照组 (P <0 0 5 ) ,中剂量组和高剂量组与对照量组比较 ,进入动情周期的大鼠无显著性差异 ;( 4)各剂量组大鼠子宫和卵巢脏器系数与对照组相比均无显著性差异 ,但随浓度增加 ,各剂量组有一定的下降趋势。结论　促生长剂对大鼠有一定的雌激素样作用 。Objective To investigate the potential effects of promoting growth additive on part of reproductive function of female rats and toxic action.Methods Animal experiment was applied,and rats was treated with various doses of growth-promoting additive by oral gavage to study productive parameters and toxic index,such as age vaginal opening (VO),estrous cycle,gland/body weight coefficient.Results Compared with control group(1)Rats of lower dose group had apparently higher body weight and body weight increased at the end of the experiment(P<0.05).(2)For rats of lower dose group,age at VO was advanced significantly(P<0.05).(3)After two-week treatment,the number of lower dose rats which entered the first estrous cycle was remarkably more than that of control group(P<0.05) ,while the number of mid-dose and higher dose rats showed no obvious difference but a trend of declination.(4)Rats uterus/body weight and ovary/body weight coefficients in various groups were slightly different (P>0. 05),and also showed a trend of declination from lower to high-dose group.Conclusion Growth-promoting additive showed estrogen-like effects on rats which may have certain correlation with the concentration of the former.

关 键 词：动物促生长剂 雌性大鼠 生殖功能 毒性作用 

分 类 号：R992[医药卫生—毒理学]