复方丹参方及丹参、三七对血小板功能影响的研究概况  

Brief Review on Effects of Fufangdanshen Prescription,Dan-shen and San-qi on the Platelet Functions

作　　者：杨佳[1] 秦彩玲[1] 

机构地区：[1]中国中医研究院中药研究所,北京100700

出　　处：《中国实验方剂学杂志》2003年第2期59-62,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家重点基础研究发展规划项目 (G19990 5 44 0 3 )

摘　　要：对近年来复方丹参方及丹参、三七对血小板功能及其机理方面的药理实验研究进行了综述。复方丹参方 ,丹参粗提物、脂溶性成分、水溶性成分 ,三七总皂苷、三醇皂苷、二醇皂苷、皂苷单体 (除三七二醇皂苷外 )均有不同程度的抑制血小板聚集和粘附的作用 ,对α颗粒膜蛋白 14 0、TXA2 PGI2 系统、cAMP、Ca2 + 等方面的影响亦有相关报道。对进一步揭示复方丹参方的作用机理具有一定的参考价值。In this article,the recent pharmacological studies of fufangdanshen prescription\,Danshen and San\|qi on the platelet functions and mechanisms are summarized.Fufangdanshen prescription,the crude extract of Dan\|Shen\,lipophilic fractions\,aqueous fractions,the total notoginsenosides\,the fraction of panoxatriol saponins\,the fraction of panaxadiol saponins and the ingredients of notoginsenosides(except the fraction of panaxadiol saponins)could inhibit platelet aggregation and adhesion in different levels.Many researchers also investigated the pharmacological effects on GMP\|140\,the system of TXA\-2/PGI\-2\,cAMP\,Ca 2+ ,etc.It's valuable to write this paper for the mechanisms of fufangdanshen prescription revelations.

关 键 词：复方丹参方 丹参 三七 血小板功能 影响 药理实验研究 

分 类 号：R285.5[医药卫生—中药学]