葛根黄豆苷元衍生物DZ18在大鼠小肠的吸收动力学研究  

Studies on the Absorptive Kinetics of Daidzeid Derivative DZ18in Rats'Small Intestines

作　　者：姜铁夫 陈济民[2] 佟志清 李梓溪 袁慧星 

机构地区：[1]解放军第463医院,沈阳市110042 [2]沈阳药科大学,沈阳市110016

出　　处：《中国药房》2003年第3期141-142,共2页China Pharmacy

基　　金：国家新药研究基金资助课题 (969010555)

摘　　要：目的 :研究葛根黄豆苷元衍生物DZ18的吸收机制和吸收部位。方法 :采用在体和离体小肠回流装置 ,对DZ18的大鼠小肠吸收动力学进行研究。结果 :DZ18在体小肠胆管结扎与不结扎的最终吸收程度分别为59.2 %、58.8 % ,两者间无显著性差异。结论 :小肠不同段DZ18的吸收速率常数无明显影响 ,说明其吸收不存在部位特异性。OBJECTIVE:To study the mechanism and location of absorption of DZ18.METHODS:In this study,improved intestinal absorption experiments(in vivo,in vitro)were used to study the absorption of DZ18in rats.RESULTS:It was found that there was no significant difference in absorptive rate in rats between without and with bile duct ligation.The cumulative percentages of absorption were59.2%and58.8%.CONCLUSION:There are no significant differences among the absorptive rates at different parts of small intestine in rats,which shows that there is no specificity of intestinal segments in absorption.

关 键 词：葛根黄豆苷元 衍生物 DZ18 大鼠 小肠 吸收动力学 研究 小肠吸收 实验研究 

分 类 号：R285.5[医药卫生—中药学]