纤溶酶原激活剂抑制物-1及其基因多态性与急性心肌梗死的相关性研究  

Correlation between Plasminogen Activator Inhibitor-1 and Its Gene Popymorphism and Acute Myocardial Infarction

作　　者：尹士全 刘霜[2] 孙根义[3] 阚跃东 谢鸿旗 

机构地区：[1]天津市红桥医院,300131 [2]天津市第二中心医院 [3]天津市胸科医院

出　　处：《天津医药》2003年第3期131-133,共3页Tianjin Medical Journal

摘　　要：目的 :研究纤溶酶原激活剂抑制物 -1(PAI -1)活性及其等位基因多态性与急性心肌梗死(AMI)之间的关系 ,从基因水平揭示AMI发病的危险因素。方法 :AMI组55例、对照组48例健康者分别应用特异性寡核苷酸点膜杂交技术 ,进行PAI -1启动子区4G/5G多态性分析 ,用发色底物法测定血浆PAI-1活性。结果 :AMI组和对照组中4G/4G基因型的血浆PAI -1活性水平最高 ,与4G/5G基因型、5G/5G基因型比较有显著性差异(P<0.01)。AMI组中4G/4G纯合子基因型频率明显高于对照组(P<0.05)。结论 :血浆PAI -1活性增高是AMI发病的危险因素之一 。Objective:To investigate the correlation between plasminogen activator inhibitor-1(PAI-1)and its gene popymorphism and acute myocardial infarction(AMI).Methods:The4G/5G popymorphism in PAI-1gene promotor region was analyzed by specific oligonucleotide hybridization in55patients with AMI and48normal controls.The plasma PAI-1activity was asayed with chromogenic substrate.Results:The PAI-1level in4G/4G hormozygous was significantly higher than those in4G/5G heterozygous and5G/5G hormozygous (P<0.01).The4G/4G hormozygous gene level in AMI was higher than that in control(P<0.05).Conclusion:The elevated plasma PAI-1activity and the4G/4G allele hormozygous genotype was the major risk genotype of AMI.

关 键 词：纤溶酶原激活剂抑制物-1 基因多态性 急性心肌梗死 相关性研究 

分 类 号：R542.22[医药卫生—心血管疾病]