存活心肌^(31)P-MR波谱的研究  

Study in human viable myocardium by ^(31)P magnetic resonance spectroscopy

作　　者：赵海涛[1] 陆军[1] 张卓立[1] 黄志兰[1] 李俊峡[2] 高峰[3] 张胜利[3] 

机构地区：[1]第四军医大学西京医院放射科,陕西西安710032 [2]第四军医大学西京医院心内科,陕西西安710032 [3]第四军医大学西京医院心外科,陕西西安710032

出　　处：《心脏杂志》2003年第1期49-51,共3页Chinese Heart Journal

摘　　要：目的 :探讨存活心肌高能磷酸盐变化。方法 :用心脏电影磁共振成像 (Cine_ MRI)和 2 D- CSI31 P磁共振频谱(MRS)研究 17例急性前壁心肌梗死 6h内成功再灌注患者 6± 2 d后的磷酸肌酸 (PCr)与 ATP的比值 ;其中 16例患者急性前壁心肌梗死后 3 9± 8d再次做 31 P- MRS及心脏 Cine - MRI检查。7位健康自愿者作对照组参加研究。结果 :患者心功能明显恢复心肌阶段 (存活心肌 ) PCr/ ATP比值 ,早期为 1.5 3± 0 .16,晚期为 1.5 7± 0 .10 ,早期与晚期比较 ,早期与正常对照组 (1.5 9± 0 .13 )比较均 P>0 .0 5。结论 :国人存活心肌状态下心肌 PCr/AIM: To investigate whether alterations in cardiac high energy phosphates occur in postischemic viable myocardium. METHODS: We studied 17 patients with a first anterior myocardial infarction (MI) who underwent successful reperfusion within 6h of onset of chest pain. These patients underwent 31 P MRS and cine MRI after MI 6±2 days for measurement of left ventricular regional function and relative high energy phosphate metabolisms. 16 patients underwent the second 31 P MRS and Cine MRI after MI 39±8 days. Seven Volunteers served as control subjects. RESULTS: Cine MRI demonstrated significant recovery of regional function where no difference was found between early cardiac phosphocreatine PCr/ATP ratios in patients and control subjects (1.53±0.16 vs 1.59±0.13, P >0.05) or between early and late PCr/ATP ratios in patients (1.53±0.16 vs 1.57±0.10, P >0.05). CONCLUSION: Relative cardiac high energy phosphates are not depleted in viable myocardium.

关 键 词：存活心肌 磁共振成像 磁共振频谱 高能磷酸盐 

分 类 号：R445.2[医药卫生—影像医学与核医学] R542.2[医药卫生—诊断学]