10种抗结核药物对结核分枝杆菌的体外抑菌试验结果分析  

Analysis on Result of Antimicrobial Susceptibility Testing of 10 Type Antituberculosis Drug

作　　者：施旭东[1] 王雷[1] 

机构地区：[1]南京市胸科医院,江苏南京210029

出　　处：《实用医技杂志》2003年第3期174-175,共2页Journal of Practical Medical Techniques

摘　　要：目的 :探讨结核分枝杆菌 (Mycobacterium Tuberculosis MTB)对抗结核药物的体外耐药情况。方法 :采用绝对浓度法对 840株结核杆菌和 2 69株多耐药结核杆菌 (Multidrug- resistant- Tuberculosis MDR- TB)进行 10种抗结核药物体外抑菌试验。结果 :在 840株 MTB中 10种药物耐药率最高的为 RFP(43 .8% ) ,最低为 CPM(4.6% ) ,而 2 69株MDR- TB的耐药率最高为 SM(74.6% ) ,最低为 CPM(11.9% )。结论 :应加强抗结核药物的耐药性监测 。Objective To study the situation of mycobacterium tuberculosis(MTB) resistance to antituberculosis drug in extracorpora.Methods Determine the resistance in extracorpora of 10 type antituberculosis drug with 840 strains MTB and 269 strains multidrug resistant tuberculosis(MDR TB) by method of absoluted concentration.Results Of 840 strains MTB,the highest resistant rate is RFP(43.8 %),the lowest is CPM(4.6 %).Of 269 strains MDR TB,the highest resistant rate is SM(74.6 %),the lowest is CPM(11.9 %).Conclusion Determining resistance of antituberculosis drug must be strengthened. Choosing reasonable and efficient therapy should depend upon the result of antituberculosis drug testing.

关 键 词：抗结核药 结核分枝杆菌 体外抑菌试验 

分 类 号：R965.3[医药卫生—药理学]