褪黑素对中老年人失眠的疗效及安全性研究  

STUDIES ON CURATIVE EFFECT OF MELATONIN ON AGRYPNIA IN MIDDLE-AGED AND ELDERLY PEOPLE AND ITS SAFETY

作　　者：赵瑛[1] 刘颖[1] 石勇铨[1] 刘志民[1] 彭树勋[2] 

机构地区：[1]第二军医大学长征医院,上海200003 [2]香港大学医学院生理系

出　　处：《解放军医学杂志》2003年第3期234-235,共2页Medical Journal of Chinese People's Liberation Army

摘　　要：通过给予中老年失眠患者服用不同剂量褪黑素 ,观察入睡时间、起效时间、睡眠持续时间及药物的不良反应 ,随机盲法研究褪黑素对中老年失眠患者的疗效和安全性。结果显示 ,褪黑素治疗中老年失眠患者疗效较好 ,患者服药后入睡时间缩短 ,睡眠持续时间延长。其疗效与剂量有明显关系 ,无不良反应发生。研究认为 ,褪黑素治疗中老年失眠疗效确切 。Elderly agrypnia patients were given with different doses of melatonin. Patients′ falling a sleep time, coming into effect time, sleep lasting time and adverse effect of melatonin were observed to study the effect and safety of melatonin on elderly agrypnia patients. The results showed melatonin could effectively improve the agrypnia suffered by elderly patients. Patients′ falling a sleep time was shortened and sleep lasting time prolonged after taking melatonin. The effect of melatonin increased along with increase of its dose.There were no adverse effects observed. Our study indicates that melatonin has a good safety profile and significant effects on agrypnia suffered by elderly patients.

关 键 词：褪黑素 入睡和睡眠障碍 治疗结果 安全性 

分 类 号：R969.4[医药卫生—药理学] R585[医药卫生—药学]