褪黑素对性激素及排卵的调节作用研究  

INVESTIGATION OF MELATONIN ON SEX HORMONES AND OVULATION

作　　者：辜荣飞 邹俊杰[2] 刘志民[2] 段继才 彭树勋[4] 

机构地区：[1]上海市普陀区妇幼保健院,上海200003 [2]第二军医大学长征医院 [3]上海新申医疗科技研究所 [4]香港大学医学院生理系

出　　处：《解放军医学杂志》2003年第3期236-237,共2页Medical Journal of Chinese People's Liberation Army

摘　　要：为探讨褪黑素 (Mel)对卵泡刺激素(FSH)、黄体生成素 (LH)及雌激素 (E2 )和排卵的影响 ,选择健康育龄女性 10 0人 ,随机分为 5组 ,分别口服Mel0mg、12mg、3 0mg、75mg和 3 0 0mg,连续 3个月 ,用全自动酶联免疫分析法检测 5组的基础和服用Mel后FSH、LH和E2 水平 ,用B超监测优势卵泡发育情况。结果发现 ,用药后血清FSH、LH、E2 较用药前有显著降低 ,且随着Mel剂量的增加 ,性激素的水平下降越显著 ,有明显的剂量依赖性 ,优势卵泡的发育明显受抑 ,直径显著缩小。研究结果表明 ,给予外源性的Mel可能直接通过下丘脑 垂体 卵巢轴的Mel受体 。To investigate the effect of melatonin(Mel) on follicle-stimulating hormone(FSH), luteinizing hormone(LH), estradiol(E 2) and ovulation, 100 healthy women were divided into 5 groups to take 0mg, 12mg, 30mg, 75mg, and 300mg Mel per day, respectively, for 3 months. The levels of FSH, LH, E 2 were determined by enzyme-linked immunosorbent assay(ELISA) before and after medication, the development of dominant follicle was detected by ultrasound. We have found that the levels of FSH, LH and E 2 were all lower and the dominant follicle was smaller than those of the control (0mg) group at 3 months. In this study we demonstrated the direct involvement of melatonin in modulation of the female reproductive system in a dose-dependent manner, and it may be put into effect through melatonin receptors in human hypothalamus-pitutary-ovary cells.

关 键 词：褪黑素 雌激素类 卵泡刺激素 黄体生成素 超声 

分 类 号：R588[医药卫生—内分泌] R585[医药卫生—内科学]