内皮功能障碍在实验性血管痉挛发生中的作用  

ROLE OF ENDOTHELIUM DYSFUNCTION IN EXPERIMENTAL VASOSPASM

作　　者：傅强[1] 傅向阳[1] 陈新[1] 

机构地区：[1]第一军医大学珠江医院,广州510282

出　　处：《解放军医学杂志》2003年第3期259-261,共3页Medical Journal of Chinese People's Liberation Army

基　　金：全军医药卫生科研基金资助课题 (编号 0 1MA1 39)

摘　　要：为研究内皮功能障碍与实验性血管痉挛的关系 ,将 2 8只新西兰白兔分成假手术对照组 (n =8)、普通饮食组 (n =8)和高胆固醇饮食组 (n=12 ) ,通过血管造影观察球囊内皮剥脱前后和喂养 8周后麦角新碱诱发血管痉挛情况以及乙酰胆碱诱导的内皮依赖性舒张功能变化情况。血管造影显示 ,在高胆固醇饮食组麦角新碱可以诱导出明显的血管痉挛 ,且痉挛血管节段乙酰胆碱诱导的内皮依赖性的舒张功能受损。痉挛血管收缩反应性的升高与内皮功能的损伤呈正相关。To investigate the relationship between endothelium dysfunction and experimental vasospasm, twenty-eight New Zealand white rabbits were randomly allocated into three groups: sham operation control group(Group 1, n=8), balloon endothelial denudation + normal diet group (Group 2, n=8) and balloon endothelial denudation + hypercholesterol diet group (Group 3, n=12). Angiography was performed to detect the vasospasm induced by ergonovine and endothelium-dependent vasodilator response induced by acetylcholine before and immediately after denudation and 8 week later. Visible vasospasm was induced at the denuded sites in group 3, and endothelium dysfunction was also found in the same locations. Positive correlation was showed between vasospasm and endothelium dysfunction. Endothelium dysfunction resulted from balloon endothelial denudation and hypercholesterolemia may play an important role in the pathogenesis of experimental vasospasm.

关 键 词：冠状血管痉挛 内皮 血管 发病机制 

分 类 号：R543.3[医药卫生—心血管疾病]